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30 Cards in this Set
- Front
- Back
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In the elderly what happens to renal fxn, Cr. Cl., and liver microsomal MFO Phase I?
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Decrease
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By how much does the half life of benzos and barbituates increase in the elderly?
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50-150%
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Elderly are more sensitive to resp. depression with opiods...when should we not restrict their usage?
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Chronic painful conditions (Cancer)
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This drug blocks NMDA receptors and may slow progression of Alzheimers
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Memantine
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These 3 drugs inhibit AchE and increase Ach release to improve Alzheimers
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Donepezil
Rivasatigmine Galantamine |
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ACE inhibitors are less useful for HTN in the elderly unless what conditions are present?
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Heart failure
DM |
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If elderly pt is takin med for HTN, what should be checked?
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Orthostatics
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What will increase the likelyhood of a digitalis arrythmia in the elderly
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hypo K
hypo Mag hypoxemia atherosclerosis |
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Where is angiotensinogen released from?
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Liver
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Angiotensinogen is converted to Angiotensin I by what?
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Renin
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Renin is relased from where?
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Kidneys
(juxtaglomerular cells) |
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What will signal renin release?
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Decreased renal stretch
Decreased Na+ to distal tubule increased SNS |
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What converts Angiotensin I to Angiotensin II?
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ACE
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What action does Angiotensin II have on blood vessels?
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Vasoconstrictor
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What converts Angiotensin II to Angiotensin III?
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Aminopeptidase
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What converts Angiotensin III to peptide fragments?
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Angiotensinases
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What are the 2 functions of ACE?
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Convert Angiotensin I to II
Convert bradykinin to inactive fragments |
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What effects does bradykinin have on the body
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Vasodilation arteriole s m
Cough Angioedema |
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Angiotensin II receptor antagonist that can be given IV?
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Saralasin
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Another name for ADH
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vasopressin
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Action of ADH
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Vasoconstiction and
Inc, water reabsorbtion in kidneys |
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PGE 1 analog, helps prevent peptic ulcers
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Misoprostol
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Primanry component in slow reacting substance of anaphylaxis
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Leukotrines
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What is Misoprostol combined with to terminate pregnancy?
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Mifepristone
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Synthetic PGE2 administered vaginally to induce abortio 2nd trimester
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Dinoprostone
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What two PG can terminate pregnancy or facilitate labor?
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PGE2
PGF 2alpha |
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Why should ASA not be used for dysmenorrhea?
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inhibits platelet TXA2= inc. bleeding
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PGE1 intracavernosal injection for ED
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Alprostadil
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How do corticosteroids help with respiratory?
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inhibit synthesis LT, PG
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Medication that inhibits release of LT, PG, histamine in lungs
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Cromolyn
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