Ch 49 Antivirals + Oneliners Lecom

Front 1

DOC for influenza A

Back 1

Amantadine

Front 2

DOC for RSV

Back 2

Ribavirin

Front 3

DOC for CMV retinitis

Back 3

Ganciclovir

Front 4

SE for ganciclovir

Back 4

Neutro, leuko and thrombocytopenia

Front 5

Anti–viral agents associated with Stephen Johnson syndrome

Back 5

Nevirapine, amprenavir

Front 6

HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism

Back 6

Protease inhibitors

Front 7

Antivirals that are teratogens

Back 7

Delavirdine, efavirenz, and ribavirin

Front 8

Antivirals associated with neutropenia

Back 8

Ganciclovir, zidovudine, saquinavir, and interferon

Front 9

HIV med used to reduce transmission during birth

Back 9

AZT (zidovudine)

Front 10

MOA for Acyclovir

Back 10

inhibits viral DNA sysnthesis 1. Competition with deoxyGTP for viral DNA polymerase 2. chain termination

Front 11

DOC for herpes simplex encephalitis and neonatal HSV infection

Back 11

Intravenous acyclovir

Front 12

Greater t1/2 than acyclovir

Back 12

Valcyclovir

Front 13

MOA for Docosanol (Abreva)

Back 13

Inhibits fusion between plasma membrane and HSV envelope

Front 14

What is required to activate Ganciclovir

Back 14

protein kinase phosphotransferase UL97

Front 15

What drug would you use to treat CMV

Back 15

Ganciclovir

Front 16

What is the differences in SE Ganciclovir vs Acyclovir

Back 16

Ganciclovir has dose limiting hematoxicity

Front 17

What drugs increase the levels of Ganciclovir

Back 17

Probenecid & trimethoprim

Front 18

What dual therapy is effective in delaying CMV retinitis

Back 18

Ganciclovir & Fosarnet

Front 19

MOA of Foscarnet

Back 19

inhibits herpesvirus DNA & RNA polymerase & HIV reverse transcriptase

Front 20

What drugs should be avoided when treating with Foscarnet due to nephrotoxicity

Back 20

amphotericin B, pentamidine, aminoglycosides, Cidofovir

Front 21

SE of Foscarnet

Back 21

Hypocalcemia

Front 22

Pt is on Pentamidine IV for PCP what drug should be avoided?

Back 22

Foscarnet

Front 23

Drug used against resistant strains of CMV or HSV

Back 23

Cidofovir (does not depend on thymidine kinase)

Front 24

IV cidofovir must be given with…

Back 24

Probenecid to block active tubular secretion to decrease nephrotoxicity

Front 25

What drugs are not useful against HIV-2

Back 25

NNRTI's

Front 26

Characteristics of NRTI's

Back 26

1. prodrugs 2. Nonspecific kinase 3. Bone Marrow supression

Front 27

NRTI's associated with dyslipidemia and insulin resistance

Back 27

Zidovudine and Stavudine

Front 28

NRTI with significant allergy SE

Back 28

Abacavir (ABC)

Front 29

NRTI with risk of peripheral distal sensory neuropathy

Back 29

Didanosine (DDI), Zalcitabine

Front 30

CI for taking Emtricitabine (FTC)

Back 30

Children, Prego, renal or hepatic failure, metronidazole, disulfiram

Front 31

Drug used prophylaxis in reducing HIV acquisition

Back 31

Emtricitabine (FTC), Tenofovir

Front 32

Common mutation in Emtricitabine and Lamivudine

Back 32

M184V/I

Front 33

Discontiuation of Lamivudine (ETC) is associated with hepatitis, why?

Back 33

Lamivudine treats both HIV & HBV

Front 34

Lmivudine works synergistically with

Back 34

Zidovudine(AZT) and Stavudine

Front 35

Drug favored over AZT due to decreased myelosuppression

Back 35

Stavudine (d4T)

Front 36

Which drug should be avoid with lactose intolerance

Back 36

Tenofovir

Front 37

SE of Tenofovir

Back 37

bone toxicity (osteomalacia)

Front 38

What drug inhibits Zalcitabine in vitro?

Back 38

Lamivudine

Front 39

MOA of Zidovudine (AZT)(ZDV)

Back 39

blocks DNA polymerase

Front 40

Which drug is the most hepatotoxic of the NRTIs

Back 40

Zidovudine (AZT) (ZDV)

Front 41

Characteristics of NNRTI's

Back 41

1. Not Pro drug 2. No bone marrow suppression 3. metabolism through CYP

Front 42

Which NNRTI prolongs the elimination of indinavir and saquinavir allowing PID

Back 42

Delavirdine

Front 43

SE of Efavirenz (NNRTI)

Back 43

Nightmares

Front 44

NNRTI that prevents vertical transmission

Back 44

Nevirapine

Front 45

Common things among Protease inhibitors

Back 45

1. Aspartate protease 2. insulin resis 3. QT prolongation

Front 46

PI that has least amount of dyslipidemia

Back 46

Atazanavir

Front 47

Pi that must be co-administered with ritonavir

Back 47

Darunavir

Front 48

PI that is CI in pts with sulfa allergy

Back 48

Fosamprenavir & Tipranavir

Front 49

PI with most common SE dyslipedemia

Back 49

Indinavir

Front 50

Which PI is contraindicated with rifampin

Back 50

lopinarvir/ritonavir

Front 51

Which PI can be admisitered to PREGO

Back 51

Nelfinavir

Front 52

Which PI is most CI in someone with QT prolongation

Back 52

Ritonvair

Front 53

MOA for Enfuvirtide

Back 53

binds to gp 41 subunit of viral envelope glycoprotein, prevents conf. change

Front 54

SE of enfuvirtide

Back 54

painful erythematous nodules

Front 55

MOA for Maraviroc

Back 55

binds to CCR5

Front 56

Resistance to Maraviroc is associated with

Back 56

V3 loop of gp 120

Front 57

SE Maraviroc

Back 57

CYP3A, postural hypotension, hepatox, increased cardiovascular risk

Front 58

MOA of Raltegravir

Back 58

binds integrase (inhibits strand transfer and final step)

Front 59

MOA of Ribavirin

Back 59

inhibits viral RNA dependent Polymerase

Front 60

Drugs that affect uncoating

Back 60

Amantadine & Rimantadine

Front 61

SE of Amantadine

Back 61

Atropine like, livedo reticularis

Front 62

Areosol given to infants with RSV

Back 62

Ribavirin