Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/16

Click to flip

16 Cards in this Set

  • Front
  • Back
available bisphosphonates
alendronate, etidronate, risedronate, pamidronate, tiludronate, zoledronic acid
MOA of bisphosphonates
inhibits osteoclast bone resorption
uses of bisphosphonates
osteoporosis, Paget's disease, osteolytic bone lesions, and hypercalcemia frrom malignancy
major SE of bisphosphonates
chemical esophagitis
bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
etidronate
used for prevention of postmenopausal osteoporosis in women
estrogen (HRT- hormone replacement therapy)
increase bone density, also being tested for breast CA tx
raloxifene (SERM)
used especially in postmenopausal women, dosage should be 1500 mg
calcium
vitamin to be coadministered with calcium to ensure proper absorption
vitamin D
cinacalcet
lower PTH by activatin Ca-sensing receptor in parathyroid gland- oral Tx of secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in those with parathyroid carcinoma
bisphosphonates with daily oral dosing
alendronate, risedronate, ibandronate
bisphosphonates with weekly oral dosing
alendronat, risedronate
bisphosphonate with monthly oral dosing
ibandronate
bisphosphonate with quarterly injection
ibandronate
bisphosphonate with annual infusion
zoledronate
higher doses of bisphosphonates used to treat hypercalcemia have been associated with
renal impairment and osteonecrosis of the jaw