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16 Cards in this Set

  • Front
  • Back
available bisphosphonates
alendronate, etidronate, risedronate, pamidronate, tiludronate, zoledronic acid
MOA of bisphosphonates
inhibits osteoclast bone resorption
uses of bisphosphonates
osteoporosis, Paget's disease, osteolytic bone lesions, and hypercalcemia frrom malignancy
major SE of bisphosphonates
chemical esophagitis
bisphosphonates that cannot be used on continuous basis because it caused osteomalacia
used for prevention of postmenopausal osteoporosis in women
estrogen (HRT- hormone replacement therapy)
increase bone density, also being tested for breast CA tx
raloxifene (SERM)
used especially in postmenopausal women, dosage should be 1500 mg
vitamin to be coadministered with calcium to ensure proper absorption
vitamin D
lower PTH by activatin Ca-sensing receptor in parathyroid gland- oral Tx of secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in those with parathyroid carcinoma
bisphosphonates with daily oral dosing
alendronate, risedronate, ibandronate
bisphosphonates with weekly oral dosing
alendronat, risedronate
bisphosphonate with monthly oral dosing
bisphosphonate with quarterly injection
bisphosphonate with annual infusion
higher doses of bisphosphonates used to treat hypercalcemia have been associated with
renal impairment and osteonecrosis of the jaw