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44 Cards in this Set
- Front
- Back
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Bowen's disease
extends down? spares? |
extends down follicles
spares acrosyringia |
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Bowen's Histo?
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loss of granular layer w parakeratosis
extends down follicles spares acrosyringia EYELINER EFFECT normal appearing basal layer |
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Bowen's arise from?
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Follicular epithelium
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Bowen's large pale cells in epidermis?
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Pagetoid spread
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ERythorplasia of Queyrat HPV?
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HPV 16
uncircumcised |
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Bowenoid Papulomatosis
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look like warts
low mal histo: HPV like change, mitoses HPV 16 |
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CK 7
Paget's vs Bowens |
CK7 + PAGETS
CK7 -/+ Bowens |
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54kD CK
Paget's vs Bowens |
54kD + PAGETS
54kD - Bowens |
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66 kD
Pagets vs Bowens |
66kD - Pagets
66kD + Bowens |
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Mucin
Pagets vs Bowens stains? |
Mucin + Pagets
Mucin - Bowens Mucicarmine fro glandular form of Pagets |
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CEA+
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Pagets
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3 syndromes assoc w BCC?
inheritance |
Gorlins (AD)
Bazex (x-linked dominant) Rombo (AD) |
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Fibroepithelioma of Pinkus
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fleshy tan lesion lower back
looks like seb k anastomosing ribbons of cells around lobular areas of stroma |
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SCC stains
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EMA+
high MW ck+ involucrin +/- lysozyme - desmin - vimentin + (spindle cell) Ki67 (MIB-1) + |
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SCC spindle cell stain?
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vimentin
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Group of pts w higher SCC?
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renal transplant pts w 18 fold increase in SCC
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SCC mets?
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1 - 5%
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Features of SCC w high met rate?
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Marjolin's ulcer
Location: lips, ears, genitals Depth > 4 mm, Diameter > 2 cm immunocompromise Perinerual invasion poorly diff or acantholytic types arrising in Bowen's disease |
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Acantholytic SCC
stains? |
Adenoid/Pseudoglandular
mucicarmine - CK7 - CK 5/6+ CK903+ vs adenoca |
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SCC spindle cell stains?
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pancytokeratin +
HMW Keratin + |
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Atypical Fibroxanthoma (AFX) stains?
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CD68 +
vimectin + differential for spindle cell ddx |
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Angiosarcoma stains?
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CD31+
CD34 + less |
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DFSP
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vimentin+
CD34+ |
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Leiomyosacrcoma
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desmin+
actin+ vimentin+ |
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spindle cell ddx for SCC spindle cell
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spindle cell SCC
atypical fibroxanthoma Angiosarcoma DFSP Leiomyosarcoma |
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Verrucous Carcinoma HPV?
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HPV 6, 11
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Buschek-Lowenstein
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giant condyloma of anus
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Epithelioma Cuniculatum
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plantar foot
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oral florid papillomatosis
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Ackerman's tumor
verrcous ca in mouth |
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Akerman's Tumor
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oral florid papillomatosis
verrucous ca in mouth |
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KA grow path eccrine coils?
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no
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Syndromes w multiple KAs?
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Muir-Torre
Ferguson Smith Grzybowski |
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Muir-Torre gene?
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MSH2, MILH1
seb neoplasms GI mal |
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Ferguson Smith
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crops of self healing KAs
TRAUMA SCOTTISH TEENS |
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Grzybowski
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rare
SPORADIC generalized eruption of KAs MUCOSAL older pts |
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Lentigo Simplex precursor to?
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jxnal nevus
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Lentigo simplex melanocytes?
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increase single # of melanocytes
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Lentigo Simplex histo?
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increase single # melanocytes rete ridges
no nesting pig basal ko dirty feet |
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2 Syndromes assoc w Lentigo Simplex? Inheritance? Genes?
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LEOPARD SYNDROME AD(PTPN11)
CARNEY COMPLEX AD(PRKAR1A) |
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LEOPARD SYNDROME clinical?
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Lentigo
ECG abnormalities Ocular hypertellorism Pulmonary stenosis Abnormal genitalia Retardation growth Deafness |
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LEOPARD SYNDROME inheritance? gene?
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AD
PTPN11 gene (allelic to Nooman Syndrome) |
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CARNEY Complex clinical? Inheritance? Gene?
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NAME: nevi,atrial myxoma, Myxoid skin tumors, Endocrine abnormalities
LAMB SYNDROME: Lentingines, Atrial myxomna, mucocutaneous Myxomas, Blue nevi AD PRKAR1A |
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NAME SYNDROME
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CARNEY Complex
nevi atrial myxoma mxyoid skin tumors endocrine |
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LAMB SYNDROME
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CARNEY complex
Lentigo Atrial Myxoma Mucocutaneous Myxomas Blue Nevi |
