Ch 24 Antihypertensive Agents

Front 1

Drugs that inhibit the function of both central (brain) and peripheral sympathetic postganglionic neurons by depleting their stores of norepinephrine and serotonin, resulting in a hypotensive effect. Reserpine is the only currently available drug in this class in the United States.

Back 1

adrenergic neuronal blocker

Front 2

Drugs that primarily cause arterial and venous dilation through action on peripheral sympathetic neurons.

Back 2

alpha1-blockers

Front 3

Medications used to treat hypertention.

Back 3

antihypertensive agents

Front 4

Amount of blood ejected from the left ventricle, measured in liters per minute.

Back 4

cardiac output

Front 5

Drugs that modify the function of the sympathetic nervous system in the brain by stimulating alpha2-receptors, which has a reverse sympathetic effect, causing decreased blood pressure.

Back 5

centrally acting adrenergic agents

Front 6

An elevated systemic arterial pressure for which no cause can be found and that is often the only significant clinical finding.

Back 6

essential hypertension (also called primary or idiopathic hypertension)

Front 7

Agents that prevent nerves from responding to the action of acetylcholine by occupying the receptor sites for acetylcholine (i.e., nicotinic receptors) on sympathetic and parasympathetic nerve endings.

Back 7

ganglionic-blocking agents

Front 8

A common, often asymptomatic disorder in which blood pressure persistently exceeds 140/90 mm Hg.

Back 8

hypertension

Front 9

The receptor and site for action for acetylcholine in both the parasympathetic and sympathetic nervous systems. They are located at the junction of the pre- and postganglionic neurins of both of these systems.

Back 9

nicotinic receptor

Front 10

A common side effect of adrenergic drugs involving a sudden drop in blood pressure when patients change position, especially when rising from a seated or horizontal position.

Back 10

orthostatic hypotension

Front 11

A drug that is inactive in its present form and must be biotransformed in the liver to its active form.

Back 11

prodrug

Front 12

Any one of more than 20 alkaloids derived from the root of a climbing shrub; used in the treatment of hypertension in the form of the drug reserpine.

Back 12

Rauwolfia alkaloid (from the plant Rauwolfia serpentina)

Front 13

High blood pressure associated with several primary diseases, such as renal, pulmonary, endocrine, and vascular diseases.

Back 13

secondary hypertension