Ch 19 Immediate Hypersensitivity

Front 1

Anaphylaxis

Back 1

prolonged bronchioconstriction, mostly attributable to lipid mediator and some to mast cells

Front 2

Uticaria

Back 2

the wheal and flare response

can also include response to food allergies

Front 3

rhinitis

Back 3

hay fever, mostly attributable to mast and lipid mediator

conjunctivits

Front 4

how are mast cells activate

Back 4

after B cells have differentiated into plasma cells...

the Ab bind to allergen

immune complex binds to FceRI on mast cell surface

now sensitized as it is saturated
but the FceRI are not localized

upon secondary response, the FceRI migrate towards each other

signal sent out as the FceRI become cross-linked

Front 5

B cell activation that leads towards mast cell activation

Back 5

must start w/ allergic B cell

IgM or IgD on surface must bind to allergen

now endocytosed, processed and presented to TH2 cell

TH2 cell helps B cell to isotype switch b/c
IL-4
IgE

B cell dif into plasma cell, secreting Ab

Front 6

Composition and signaling of FceRI

Back 6

1 a: binds the IgE

1 b: 1 ITAM (CD3)

2g: 1 ITAM (z)

functions like TCR and starts messaging to
Lyn, Syk, LAT, PLCg, IP3, DAG,PKC

Front 7

3 actions of FceRI binding

Back 7

Granule release

Lipid Mediator synth and release (2nd longest b/c already half made)

Cytokine synth and release (3rd longest b/c need txt)