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9 Cards in this Set
- Front
- Back
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beta blockers Mechanisms of Actions |
block stimulation of beta adrenergic receptors by competing norepinephrine, and epinephrine -beta blocking drugs that are selective are called (cardioselective beta blockers, or beta1blockers) -beta 2 blockers are located primarily on smooth muscle -when beta2 receptors in bronchial are blocked, is bronchial smooth muscle contraction and narrowing of the airways
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beta blockers Mechanism of actions continued... |
cardioselectivce beta1 blockers block beta 1 receptors on surface of the heart, reduces myocardial stimulation, which in turns reduces heart rate, slows conduction through AV node, prolong SA node recovery, decreases myocardial oxygen demand by decreasing myocardial contractility force
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beta blockers indications |
angina, MI, cardiac dysrhythmias, hypertension and heart failure
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beta blockers ending |
-olol, lol example: labetalol, atenolol |
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beta blockers indications for angina |
works by decreasing demand for myocardial energy and oxygen consumption, which helps shift the supply/demand ratio supply side and allows more oxygen to go to the heart muscle which helps to relieve pain of heart muscle due to lack of oxygen |
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contraindications |
known drug allergies -may include uncompensated heart failure, cardiogenic shock, heart block or bradycardia, pregnancy, sever pulmonary disease, Raynaud's disease |
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adverse effect of beta blockers |
-extensions of their pharmacologic activity -most are mild and diminished with time -some serious effects bc of acute withdrawal may exacerbate underlying angina, precipitate an MI, or cause rebound hypertension -can interfere with normal responses to hypoglycemia, such as tremor, tachycardia, and nervousness |
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toxicity and management of overdose |
-for both oral and injectable dodge forms, treatment consists of primarily of symptomatic and supportive care |
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interactions |
-most drug interactions with beta blockers result from either additive effects of coadministered meds with similar mechanism of actions or the antagonistic effect of various drugs -nonselective beta blockers may make the tachycardia from hypoglycemia caused by insulin and sulfonylurea |
