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22 Cards in this Set
- Front
- Back
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26. Note: so Vit D deficiency for Lack of D (diet, sunlight, congenital), Malabsorption, hepatic disease, and anticonvulsive drugs all present the same.
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26. Note: so Vit D deficiency for Lack of D (diet, sunlight, congenital), Malabsorption, hepatic disease, and anticonvulsive drugs all present the same.
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27. Pathophys of Renal Osteodystrophy?
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a. Hypophosphaturia results in hypocalcemia that then stimulates parathyroid secretion and enhanced bone turnover.
b. Additionally, diminished conversion of 25-D to 1,25-D occurs as renal damage progresses. |
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28. How would the following values present w/Renal Osteodystrophy?
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium: N or ↓
2. Serum Phosphorous:↑ 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids: Variable |
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29. Inheritance and pathophys of Vitamin-D dependent type 1 Renal tubular acidosis?
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a. Autosomal recessive
b. Believed to be due to reduced activity of 25(OH)D1, α-hydroxylase |
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30. Tx of Vitamin-D dependent type 1 Renal tubular acidosis?
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a. Responds to massive doses of Vitamin D2 or low-dose 1,25-D.
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31. How would the following values present w/Vitamin D-dependent type 1
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium:↓
2. Serum Phosphorous: N or ↓ 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids: ↑ |
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32. 5 Causes of Phosphate deficiency w/o 2° hyperparathyroidism?
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1. Genetic primary hypophosphatemia
2. Fanconi syndrome 3. Renal tubular acidosis, type II (proximal) 4. Oncogenic hypophosphatemia 5. Phosphate deficiency or malabsorption |
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33. How would the following values present w/Genetic Primary hypophosphatemia?
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium: N
2. Serum Phosphorous: ↓ 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids: N |
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34. Causes of Fanconi syndrome?
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a. Cystinosis
b. Tyrosinosis c. Lowe syndrome d. And acquired forms. |
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35. Inheritance type for Cystinosis and Tyrosinosis?
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a. AR
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36. Inheritance type for Lowe syndrome?
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a. X-linked recessive.
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37. How would the following values present w/Fanconi syndrome?
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium: N
2. Serum Phosphorous: ↓ 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids:↑ |
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38. Symptoms of Renal Tubular Acidosis type II (proximal)?
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1. Bicarbonaturia
2. Hyperkaluria 3. Hypercalciuria 4. Hypophosphatemia 5. Phosphaturia b. Rickets may result from leaching of bone calcium bicarbonate in an attempt to buffer retained hydrogen ions seen in this condition. |
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39. How would the following values present w/Renal Tubular Acidosis type II (proximal)?
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium: N
2. Serum Phosphorous: ↓ 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids: N |
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40. Pathophys of Oncogenic hypophosphatemia?
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a. Caused by tumour secretion of a phosphate-regulating gene product (PEX), which results in phosphaturia and impaired conversion of 25(OH)D to 1,25(OH)2D.
b. The tumours are often hard to detect but are often found in the small bones of the hands and feet, abdominal sheath, nasal antrum, and pharynx. c. Resolution occurs after tumour removal |
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41. How would the following values present w/Oncogenic hypophosphatemia?
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium: N
2. Serum Phosphorous: ↓ 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids: Usually normal |
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42. Pathophys of Phosphate deficiency or malabsorption?
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a. Caused by parenteral hyperalimentation or low-phosphate intake.
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43. How would the following values present w/Phosphate Deficiency or Malabsorption
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium: N
2. Serum Phosphorous: ↓ 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids: N |
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44. Inheritance of Vit D-dependent type II?
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a. AR
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45. Pathophys of Vit D-dependent type II?
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a. Auto recessive
b. Very high serum levels of 1,25D. c. May result from a 1,25 receptor-binding disorder. |
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46. How would the following values present w/Vitamin D-dependent type II (a type of end-organ resistance to 1,25-D.
a. Serum Calcium: b. Serum Phosphorous: c. Serum Alkaline phosphatase: d. Urine Amino Acids: |
1. Serum Calcium: ↓
2. Serum Phosphorous: ↓ or N 3. Serum Alkaline phosphatase: ↑ 4. Urine Amino Acids:↑ |
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47. Best diagnostic test for Vit D deficiency?!?!?!?
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a. Serum 25(OH)D
b. Calcium c. Phosphorous d. Alkaline phosphatase levels. e. Radiographs demonstrate poor bone mineralization. |
