Ceutics Sem 2 Test 6 Final New Material

Front 1

what are official limits based on

Back 1

type of active ingredient contained and the accuracy of the assay method and potency

Front 2

what assay method is used for Baclofen

Back 2

HPLC

Front 3

what is the range for Baclofen

Back 3

90-110%

Front 4

what is Baclofen used for

Back 4

muscle relaxant

Front 5

what is the assay method for Bacitracin Zinc and Ploymyxin B sulfate

Back 5

microbial assay

Front 6

what is the range for Bacitracin Zinc and Ploymyxin B

Back 6

90-130%

Front 7

wha tis Bacitracin Zinc and Ploymyxin B used for

Back 7

opthalmic ointment

Front 8

what is the assay method for Bacitracin Zinc ointment or Bacitracin Opthalmc oinment

Back 8

microbial

Front 9

what is range Bacitracin Zinc or Bacitracin Opthalmic ointment

Back 9

90-140%

Front 10

what is the assay method for benoxinate HCL

Back 10

UV spectroscopy

Front 11

what is benoxinate HCL opthalmic ointment used for

Back 11

local anesthetic

Front 12

what is the range of benoxinate HCL opthalmic ointment

Back 12

95-105%

Front 13

what is the assay method for Cephalexin capsules

Back 13

HPLC

Front 14

what is the range of cephalexin capsules

Back 14

90-120%

Front 15

what is the assay method for warfarin sodium tablets

Back 15

HPLC

Front 16

what is the range of warfarin sodium tables

Back 16

95-105%

Front 17

what is the assay method for Vit A/E capsules

Back 17

HPLC

Front 18

what is the range of Vit A/E capsules

Back 18

95-120%

Front 19

what is the most accurate assay method

Back 19

HPLC

Front 20

what is a stability indicator and why

Back 20

HPLC due to it giving sperate peaks for the active drug and decomposition product

Front 21

what are the non official limits

Back 21

90-110%

Front 22

what is most important in determing limits of active ingredients in the dosage form

Back 22

assay method

Front 23

what is the assay method for L-Ascorbic acid powder

what is the indicator?

Back 23

tritration with iodine solution using start as an indicator

each ml of 0.1N I2 solution equals 8.8 mg of acid

Front 24

what is the M.Wt. of acid in L-Ascorbic acid powder

Back 24

176

Front 25

what assay method is used in L-ascorbic acid injection

Back 25

HPLC

Front 26

what is the pH range for max stability of L-Ascorbic acid injection

Back 26

5.5-7

Front 27

why do you limit on oxalate in L-Ascorbic acid injection

Back 27

if you have too much oxalate in the injection it will precipitate out with calcium in our body

Front 28

for the monograph of L ascorbic acid oral solution what must be done

Back 28

must label the % alcohol it contains and assay it too

Front 29

what is the SP of l-ascorbic acid powder monograph

Back 29

specefic rotation done at 589 nm at 25 C

Front 30

what is the properties the of iodine solution in L-ascorbic acid powder

Back 30

it is a colored solution containing vit c as the antioxidant and therfore iodine gets reduced and loses its color (no vit c then color stays)

Front 31

what is the limit on SA in Aspirin powder

Back 31

0.1%

Front 32

what is done in the assay for Aspirin powder

Back 32

titrate with .5 NaOH

each ml equals 45.04 mg of ASA

assay involves boiling the mixture of ASA + NaOH for 10 minutes and then titrate back with an acid (THIS MEANS HYDROLYSIS AND THEN REDUCTION WITH SA TO FORM NA SALT)

Front 33

what is the purpose of NaOH and Acid in the assay of Aspirin powder

Back 33

take aspirin powder and add NaOH to hydrolyze it and consume NaOH to form Sa and HAc then titrate back with acid to neutrolize excess sodium

Front 34

what is the M.Wt. of Aspirin powder

Back 34

180.16

Front 35

what is the Eq. Wt. of Aspirin

Back 35

90.08

Front 36

what is the Eq weight of L-ascorbic acid

Back 36

88

Front 37

what assay method is used to measure ASA

Back 37

UV spectroscopy at its isobtic point and 280 nm at pH below 4

Front 38

what is the isosbestic point of ASA

Back 38

265 nm at pH above 4 and 280 nm at pH below 4

this is the wave length in which all the drug and decomposition products have the same absorption

Front 39

what are ASA effervescent tablets for oral solution made of

Back 39

made using suitable organic acids and bicarbonate/carbonate.

Front 40

what is commonly used with Na bicarbonate

Back 40

citric and tartaric acid

Front 41

what is the solution time for 2 ASA effervescent tablets

Back 41

2 tablets in 180 mL water at 17.5 (+-2.5C) should dissolve in 5 minutes

Front 42

what is the acid neutralizing capacity of ASA effervescent talbets and what does it mean

Back 42

5 mEq of acid per tablet

this means 5 mEq of acid must be neutralized

Front 43

what is the SA limit in ASA effervescent tablets

Back 43

8% THIS IS BECAUSE OF CO2

Front 44

what are the limits of Cefazolin Na powder

Back 44

89.1 to 110.1% on anhydrous basis

Front 45

what is the Sp. Rotation of Cefazolin Na powder

Back 45

-10 to -24 degrees

Front 46

what are the properties Cefazolin Na powder must have

Back 46

pH 4-6
100mg/mL solution
water no more than 6%

Front 47

what are the limits Cefazolin Injection

Back 47

90-115%

Front 48

what does Cefazolin Injection have to meet when you do the endotoxin test and what is the pH

Back 48

Bacterial endotoxins : not more than 0.15 USP units per mg of powder

pH 4.5-7

Front 49

what is the cefazolin na ophthalmic solution limit

Back 49

29.7mg to 36.3 mg per 10mL of drops

WHICH IS 90-110%

Front 50

what is the beyond use date of ophthalmic solution

Back 50

5 days

Front 51

what is the formula given for opthalmic solution

Back 51

powder 35mg
thimerosal 0.2 mg
NaCl injection(0.9%) QS to 10 mL

Front 52

what is the pH of cefazolin Ophthamic solution

Back 52

4.5 - 6

Front 53

what is thimerosal used as

Back 53

preservative

Front 54

sterility test is performed for what

Back 54

injections and solutions and pharmaceutical compounding

Front 55

what is the nonsteril test used on

Back 55

otic

Front 56

what is the % NaCl in a injection to give isotonicity

Back 56

0.9%

isotonicity won't be irritating to the eye

Front 57

what generation is cephalosporin

Back 57

2nd gen

Front 58

what generation is penicillin/methycillin

Back 58

1st gen

Front 59

when you need to test enteric coating what do you do

Back 59

gastric solution and intestinal solution stimulation

Front 60

what is the composition of Simulated Gastric Solution

Back 60

2 g NaCl
3.2 g pepsin
7mL HCl per liter
HCl is 38% solution by weight

Front 61

what is the pH of simulated gastric solution

Back 61

1.2

Front 62

what is the composition of simulated intestinal solution

Back 62

6.8g of KH2PO4
77 mL of 0.2N NaOH solution
10g of pancreatin per liter

Front 63

what is the pH of the simulated intestinal solution

Back 63

6.8

Front 64

how do you adjust the simulated intestinal solution

Back 64

0.2N HCl/NaOH

Front 65

cephazolin is a what

Back 65

cephalosporin