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6 Cards in this Set

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Charcot-Bouchard aneurysms
aneurysms of the arterioles
Saccular "berry" aneurysms
1) Derive from congenital defect in arterial wall at arterial branch points at base of brain
2) may be associated with autosomal dominant polycystic kidney disease
3) aneurysm not present at birth but develops and enlarges over time
4) rupture produces SAH at base of brain
Areas sensitive to damage by hypoxic/ischemic encephalopathy
1) hippocampus
2) cerebral cortex layers 3,4,5: laminar necrosis
3) watershed zones
4) cerebellar Purkinje cells
Complications of subarachnoid hemorrhage
1) Acute: arterial vasospasm leading to ischemia/infarction
2) Chronic: breakdown of hematoma and scarring may interfere with CSF circulation and cause hydrocephalus
Lacunar infarctions
-multiple small infacts in the brain caused by hypertension
-structures especially affected are basal ganglia, thalamus and white matter
-large numbers may lead to multi-infarct dementia, mimicking Alzheimer's disease
CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
- leads to multiple white matter infarcts and eventual dementia in young adults