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12 Cards in this Set
- Front
- Back
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Cephalosporins is a ___1___
group of ___2___ B lactam ABX Have _3__ or more R groups Manipulation of molecular structure induces more BLM ___4____ and ___5___ spectrum |
1. large
2. synthetic 3. two 4. resistance |
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Cephalosporins: Pharmokinetics
*__1__ stable than penicillins in acid *Multiple agents some available __2__ others availabe via ___3___ *Exretion primarily __4___ |
1. more
2. orally 3. injections 4. renal (rocephin excreted via bile) |
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Cephalosporins Take Home Pt
*Classified by __1___ into 4 different "generations" *As we advance from 1st to 4th generation __1__ vs. gram __2___ __3__ *Have a lot of overlap btw __4__ & __5___ *__6___ to BLM __7__ by generation |
1. coverage
2. negative 3. increases 4. agents 5. generations 6. resistance 7. increases |
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Cephalosporins:1st generation
Two Prototypes |
1. Cephalexin (KEFLEX)
2. Cefazolin (ANCEF) |
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Cephalosporins 1st generation
-good coverage on S1 & S2 -__3___ resistance occurring -covers a few gram neg: e. coli & klebsiella pn __4__ used primarily as preoperative vs __5__ & aerobic gram neg enteric __6__ |
S1. Strep
S2. Staph 3. Increasing 4. Ancef 5. Staph 6. Bacilli |
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Cephalosporin:2nd generation
Two prototypes *Similar coverage as 1st generation but has better ____3___ and gram neg ___4___ |
1. Cefaclor (CECLOR)
2.Cefuroxime(CEFZIL/ZINACEF) 3. H. influenzae 4. bacilli |
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Cephalosporins 2nd generation
*oral agents against __1___ *__2___is a good empiric therapy vs CAP in hospitals |
1. Otitis Media
2. Zinacef |
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empiric therapy definition:
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Empiric therapy is a medical term referring to the initiation of treatment prior to determination of a firm diagnosis.
Empiric antibiotics are typically broad-spectrum, in that they treat a wide variety of possible microorganisms |
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Cehpalosporins:3rd generation
Two Prototypes *Better Gram Neg -H. flu, M catarrahlis, enterobacteriacea -Fortaz & Cefoboid = anti psuedomonas |
1. Cefpodoxime (VANTIN)
2. Ceftriaxone (ROCEPHIN) |
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Cephalosporin 3rd generation
__1__ &__2__ good vs OM __1__,__2__ & claforan good vs gonorrhea other uses: -pnuemoniae, meningitis, intra abdominal, or urinary tract -lyme diseas |
1. Vantin
2. Rocephin |
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Cephalosporins 4th generation
Prototype (1) * more __2___ to BLM * similar in coverage of 3rd generation agents * not effective against __3__ or resistant __4___ |
1. Cefpime (MAXIPIME)
2. resistant 3. MRSA 4. pneumococci |
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Cephalosporin Side Effects
*few *Possible cross rxn w/ __1__ *Hypersensitivity rxns possible: rash, urticaria, drug fever, eosinophilia *Diarrhea, supra infections *Inhibit vitamin _2__ *Interaction with ___3___ |
1. Penicillin
2. K 3. Warafin (Coumadin) |
