Central Nervous System Ii: Pharmocology

Front 1

What is the MOA of Chlorpromazine/Thorazine?

Back 1

It's a conventional antipsychotic that blocks receptors for dopamine, histammine, NE, and Ach.

Front 2

IND for Thorazine

Back 2

Schizophrenia, bipolar disorder

Front 3

AE for Thorazine

Back 3

Extrapyramidal effects:mov't disorders
-acute dystonia:spasms of the tongue, face, neck, and back.
-parkinsonism: decr dopamine, slow mov't, shuffled gait, tremors
-akathisia: pacing, squirming.
-tardive dyskinesia: involuntary mov't of tongue, face, interferes with speech.
Anticholinergic Effects
Sedation
Orthostatic Hypotension
Neuroendocrine effects: inc prolactin-gynecomastia
Galactorrhea
Seizures

Front 4

DI of Thorazine

Back 4

Anticholinergics
CNS Depressants
Levadopa

Front 5

AE of Haldol

Back 5

Extrapyramidal Effects
Neuroendrocrine Effects
Dysrhythmias

Front 6

MOA of Clozaril

Back 6

Clozaril is an atypical antipsychotic, which acts by clocking receptors for dopamine, histammine, NE, Ach, and seratonin. Low affinity for dopamine, high for seratonin.

Front 7

IND for Clozaril

Back 7

Schizophrenia, bipolar disorder.

Front 8

AE of Clozaril.

Back 8

-Agranuloctytosis
-Weight gain
-Sedation
-Orthostatic Hypotension
-Diabetes
-Seizures

Front 9

DI of Clozaril

Back 9

Bone marrow suppressants

Front 10

MOA of TCAs

Back 10

Block neuronal uptake NE/seratonin. By blocking the reuptake can inc effects of transmitters. Initial response 1-3 weeks. Max response 1-2 months.

Front 11

IND of TCAs

Back 11

Depression, bipolar disorder

Front 12

AE of TCAs

Back 12

-Sedation
-Orthostatic Hypotension
-Anticholinergic Effects
-Cardiac Toxicity
TOXIC: combined effects of cardiac toxicity/anticholinergic effect

Front 13

DI of TCAs

Back 13

-MAOIs
-CNS depressants
-Anticholinergics
-Direct acting sympathomimetics
-Indirect acting sypmathomimetics

Front 14

MOA of SSRIs/Prozac

Back 14

Selectively inhibit the reuptake of seratonin which intensifies transmission at seratonergic synapses, inc seratonin. response in 1-3 weeks.

Front 15

IND of SSRIs/Prozac

Back 15

-depression
-OCD
-Bulimia, PMS
-unlabelled use: anxiety disorders, alcoholism, ADHD, migraines.

Front 16

AE of SSRIs/Prozac

Back 16

-nausea
-HA
-CNS stimulation
-Sexual dysfunction
-Weight gain
-Seratonin syndrome
-Withdrawal syndrome

Front 17

DI of SSRIs/Prozac

Back 17

-MAOIs
-Warfarin
-TCAs, lithium

Front 18

MOA of S/NRIs

Back 18

Block the reuptake of seratonin/NE

Front 19

What is the MOA of MAOIs

Back 19

Inhibit inactivation of NE/seratonin, which incr the amount and intensifies responses at adrenergic and seratonergic junctions.

Front 20

What is the IND of MAOIs?

Back 20

Depression, bulimia, OCD, panick attacks.

Front 21

What are the AEs of MAOIs?

Back 21

-CNS stimulation
-Orthostatic hypotension
-Hypertensive crisis from dietary tyramine.

Front 22

DIs of MAOIs

Back 22

-TCAs and SSRIs
-CNS depressants
-Demerol
-Indirect acting sympathomimetics.

Front 23

MOA of Wellbutrin

Back 23

An atypical antispychotic, unclear, blocks dopamine uptake, stimulant action, similar to amphetamine.

Front 24

IND of Wellbutrin

Back 24

-Smoking cessation
- Depression

Front 25

AE of Wellbutrin

Back 25

-Agitation
-HA
-Weight loss
-Insomnia
-Seizures

Front 26

MOA of Lithium

Back 26

Unknown, controls acute manic episodes, prevent recurrence of mania or depression. Short half-life so given in divided doses, 3-4 times per day.

Front 27

IND for Lithium

Back 27

Bipolar disorder

Front 28

AE of Lithium

Back 28

-GI disturbances
-Hand tremors
-Polyuria
-Renal toxicity
-Enlargered thyroid gland, hypothyroidism

Front 29

AE of Lithium: LIthium toxicity

Back 29

Lithium has a narrow therapeutic range:
-Confusion, sedation
-inc in hand tremors
-blurred vision, EKG changes, seizures.

Front 30

DI of Lithium

Back 30

-Diuretics
-NSAIDS
-Anticholinergic drugs

Front 31

MOA of Benzodiazapines

Back 31

Potentiates the action of GABBA, an inhibitory neurontransmitter in CNS--inc action of GABBA--dec anxiety, sedation and muscle relaxation. Onset is immediate.

Front 32

IND of Benzodiazapines

Back 32

-Anxiety, insomnia
-Induce general anesthesia
-Seizure disorders
-Muscle spams
-Alcohol withdrawals

Front 33

AE of Benzodiazapines

Back 33

-CNS depression
-Respiratory depression
-Paradoxical effects(excitation)

Front 34

Toxicity of Benzodiazapines

Back 34

Overdose is treated with flumazenil(Romazicon)

Front 35

DI of Benzodiazapines

Back 35

CNS depressants

Front 36

MOA of Buspar

Back 36

Unknown, not a CNS depressant, no sedation, or dependence, does not interact with CNS depressants. Slow response.

Front 37

AE of Buspar

Back 37

Dizziness, nervoussness, lightheadedness, nausea.

Front 38

DI of Buspar

Back 38

Grapefruit juice

Front 39

MOA of Ambien

Back 39

Potentiates action of GAB--sedation only.

Front 40

IND of Ambien

Back 40

Insomnia

Front 41

AE of Ambien

Back 41

Daytime drowsiness

Front 42

DI of Ambien

Back 42

CNS depressants

Front 43

MOA of Ritalin

Back 43

CNS stimulant, promotes release of NE and dopamine in the CNS and PNS--results in improved focus, attention, better impulse control, less hyperactivity.

Front 44

IND of Ritalin

Back 44

ADHD, narcolepsy

Front 45

AE of Ritalin

Back 45

-Insomnia
-Growth suppression: due to appetite suppression.