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42 Cards in this Set
- Front
- Back
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Controls emotion, movement, reward mechanisms |
Dopamine |
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Dopamine is a metabolic precursor of (2) |
NE and E |
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Dopamine is derived from |
Tyrosine |
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Dopamine is stored in |
Neuronal Vesicles |
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Dopamine is released when there is |
Nerve Impulse |
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D1 and D5 |
D1 Family, Stimulatory |
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D2, D3, D4 |
D2 Family, Inhibitory |
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Production of movement
Affected in PD, S/Es of antipsychotics |
Nigrostriatal |
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Nigrostriatal composes __ of DA in brain |
75% |
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Normal cognitive function |
Mesocortical |
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Pleasure and reward |
Mesolimbic |
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Regulation of prolactin |
Tuberohypophyseal |
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Progressive neurodegenerative illness TRAP Decreases DA-producing neurons |
Parkinson's Disease |
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Drugs for PD may: DA release DA synthesis DA agonist Metabolism |
Increase Increase Increase Decrease |
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Prevents peripheral conversion of Levodopa |
Levodopa + Carbidopa |
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Long term use of Levodopa |
Fluctuation in response Loss of efficacy |
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No cheese effect |
Hypertensive Crisis |
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Selegiline + Fluoxetine |
Serotonin Syndrome |
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Seizures, Agitaiton, Diaphoresis |
Meperidine |
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5x more potent than selegiline |
Rasagiline |
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Rasagiline's neuroprotective property is due to __ group |
Propargylamine |
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DA agnosts: Dyskinesia Progress of degeneration of DA neurons |
Decreases Decreases |
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3 Ergot Derivatives |
Pergolide Cabergoline Bromocriptine |
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D1<D2 (300x) Adverse Effect: Valvular Heart Disease |
Pergolide |
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D1<D2 (50x) Tx of hyperprolactinemia |
Cabergoline |
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D1 antagonist D2 agonist (Decreases dyskinesia) |
Bromocriptine |
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Non Ergot Derivatives are agonists at __ and __ receptors |
D2, D3 |
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Aporphine alkaloid of the benzoquinoline class |
Apomorphine |
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Apomorphine is for acute, intermittent __ episodes and hypomobility w/ advanced PD |
Off |
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3 Non-Ergot Derivatives |
Pramipexole Ropinirole Rotigotine |
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Tx of signs and sx of idopathic PD alone or w/ levodopa Symptomatic tx of idiopathic restless leg syndrome |
Pramipexole |
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Same indications with Pramipexole |
Ropinirole |
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Transdermal A/E: Somnolence (causing drowsiness) |
Rotigotine |
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X catechol-o-methyltransferase leads to decrease in |
3-OMD |
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Selective and reversible COMTi (CNS and periphery) Increases delivery to CNS of levodopa No haptoxicity |
Tolcapone |
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Selective and reversible COMTi (periphery only) Hepatoxicity |
Entacapone |
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Used in the early stages of PD |
Anticholinergics |
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Anticholinergics treats |
Tremors |
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Anticholinergics has no effect in |
Bradykinesia |
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May impair cognitive function in elderly (4) |
Benztropine Trihexyphenidyl Orphenadrine Procyclidine |
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Attenuate dyskinesia |
Amantadine |
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Amantadine inhibits ACh funciton in |
Hippocampus |
