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21 Cards in this Set
- Front
- Back
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what are the cells involved in innate immunity
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phagoctes, mast cells, NK cells (capable of helping antigen specific antibodies kill targets)
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what are involved in aquired immunity
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lyphocytes (t and b cells)
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where are T cells located and what do they do
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thymus
help B lymphocytes make antibodies |
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where are B cells located and what do they do
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bone marrow
make antibodies |
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what is the primary function of innate immunity
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limit infections (try to keep infection under control till adaptive immunity can come take over)
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what are the external barriers of innate immunity
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1) skin
-physical barrier -sweat (inhibits bacteria growth b/c of pH) -pH 2) mucous membranes -cilia -coughing, wheezing -washing effect -bacteriocidal secretions (stomach acid/tears/saliva) 3)commensal organisms -flora of gut -produce inhibitory substances (lactic acid) -compete for nutrients |
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what are phagocytes
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ingest large immune complexes and remove left over debree from antibodies
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what are neutrophils
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granulocytes
-most numerous WBC in circulation (1st TO RESPOND TO INFECTION) PROVIDE DEFENCE AGAINST PYOGENIC BACTERIA polymorphonuclear - neutrophils have one nucelus w/ a lot of lobes |
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what is pus
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dead neutrophils
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where are mesangial cells
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kidney
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where are microglial cells
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brain
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what do macrophages do
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kill pathogens that are growing w/in them (TB)
-a component of the aquired immune system is needed to activate macrophages |
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what is needed for cell mediated immunity
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macrophages (for bacteria/pathogen that are have no soluble antibodies)
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what is cell mediated immunity
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not soluble, cells that are suspended in tissue/circulation
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what is humoral immunity
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something that is soluble in your circulation (antibodies are humural b/c they dissolve in your serum)
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what is a phagosome
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organelle that contains bacteria that have been engulfed
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what is a lysosome
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contains enzymes that can help digest bacteria
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what is a phagolysosome
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combination of lysosome and phagosome, contains the bacteria and the enzymes of the lysosome to kill the bacteria
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what are pathogen recognition receptors
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receptors that phagocytes have that are specefic for pathogens.
-since pathogens have molecular structures that differe from the host cell phagocytes use PRR to detect them. |
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what are some examples of Pathogen associated molecular patterns (PAMPS)
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mannose (found on surface of some pathogens but never on host cell)
N-formylmethionyl peptide (this is what proteins made from bacteria start with) |
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what are Toll Like Receptors
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they are a subset of PRR
-all have similar structures -ACTIVATE NFkB |
