Cells Of Cns And Pns Olsow

Front 1

The 3 embryological origins of the CNS/PNS

Back 1

1. Neuroectoderm
2. Neural crest
3. Mesoderm

Front 2

The neuroectoderm gives rise to these 4 CNS components

Back 2

1. CNS neurons
2. Ependymal cells
3. Oligodendroglia
4. Astrocytes

Front 3

T/F: The outer lining of ventricles make CSF

Back 3

False. Inner lining (ependymal cells)

Front 4

The neural crest gives rise to these 2 PNS components

Back 4

1. PNS neurons
2. Schwann Cells

Front 5

The mesoderm gives rise to just 1 component of the CNS

Back 5

Microglia

Front 6

T/F: The Nissl substance is the rough endoplasmic reticulum of neurons

Back 6

True

Front 7

T/F: The neuronal axons contain nissl substance

Back 7

False

Front 8

Nissl substance can be found in these 2 parts of a neuron

Back 8

Cell body and dendrites

Front 9

T/F: Neurons are permanent cells (do not divide in adulthood)

Back 9

True

Front 10

Maintenance of blood-brain barrier, physical support, repair, K+ metabolism, removal of excess neurotransmitter

Back 10

Astrocytes

Front 11

In response to injury, astrocytes induce

Back 11

reactive gliosis

Front 12

What is the astrocyte maker

Back 12

GFAP (Glial fibrillary acidic protein)

Front 13

T/F: The microglia are responsible for removing excess neurotransmitter in the brain

Back 13

False. Astrocytes

Front 14

T/F: The CNS neurons maintain the blood brain barrier

Back 14

False. Astrocytes

Front 15

The CNS phagocytes are

Back 15

Microglia

Front 16

T/F: Microglia are seen clearly in Nissl stains

Back 16

False. Not readily discernible in Nissl stains

Front 17

T/F: Microglia have large, regular nuclei

Back 17

False. Small irregular nuclei

Front 18

T/F: Microglia have abundant cytoplasm

Back 18

False. Little cytoplasm

Front 19

What is the microglial response to tissue damage

Back 19

Differentiate into large phagocytic cells

Front 20

Microglial response to HIV infection

Back 20

HIIV-infected microglia fuse to form multinucleated giant cells in the CNS.

Front 21

T/F: HIV-infected microglia fuse to form multinucleated giant cells in the CNS

Back 21

True

Front 22

The CNS cells destroyed in multiple sclerosis are

Back 22

Oligodendrocytes

Front 23

T/F: One oligodendrocyte for one CNS axon

Back 23

False. Each oligodendrocyte myelinates multiple CNS axons (up to 30 each)

Front 24

The predominant type of glial cell in white matter?

Back 24

Oligodendrocytes

Front 25

Describe oligodendrocytes in nissl stains

Back 25

Small nuclei with dark chromatin and little cytoplasm

Front 26

Term used in describing oligodendrocytes in H&E staining

Back 26

"Fried egg" appearance

Front 27

T/F: One schwann cell for multiple PNS axons

Back 27

False. One schwann cell for one PNS axon

Front 28

T/F: Schwann cells promote axonal regeneration

Back 28

True

Front 29

The PNS cells destroyed in Guillain-Barre syndrome

Back 29

Schwann cells

Front 30

T/F: Acoustic neuroma is a type of oligodendroglioma

Back 30

False. Acoustic neuroma is a type of schwannoma

Front 31

Acoustic neuroma is typically located where

Back 31

internal acoustic meatus

Front 32

Origin of schwann cells

Back 32

Neural crest

Front 33

Origin of oligodendrocytes

Back 33

Neuroectoderm

Front 34

Origin of microglia

Back 34

Mesoderm

Front 35

Origin of astrocytes

Back 35

Neuroectoderm

Front 36

What cells induce reactive gliosis in response to tissue damage

Back 36

Astrocytes

Front 37

T/F: Acoustic neuroma is typically located in the external acoustic meatus

Back 37

False. Internal acoustic meatus