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22 Cards in this Set
- Front
- Back
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Primary Lymphoid Tissue |
-Bone marrow and/or fetal liver -Thymus |
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Secondary Lymphoid Tissue |
-Lymph nodes -Spleen -Gut-associated lymphoid tissue (GALT) -Bronchus-associated lymphoid tissue (BALT) -Skin-associated lymphoid tissue -Thoracic duct -Blood |
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Virgin or Naïve Lymphocytes |
-Mature lymphocytes that have encountered or been stimulated by their specific antigen |
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Cells that are apart of the adaptive immune response |
- Lymphocytes and Plasma Cells |
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Uses for Lymphocyte Cell Surface Markers |
-Identify and count CD4+ and CD8+ cells -Establish maturity of cells -Classify diseases (Leukemias) -Monitor immunotherapy |
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Cluster of Differentiation (CD) |
-Naming system of cell surface markers -Use monoclonal antibody testing (Mab) to determine these cell surface markers |
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T Lymphocytes (T cells) |
-Cellular immunity (cell-to-cell mediated) -Undifferentiated cells start in the bone marrow then mature in the thymus -When they leave the thymus, they are CD4+ or CD8+ (T cell receptors) -Functions: antigen recognition, cellular immune reactions, regulation of antibody reactions in conjunction with B cells |
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T Cell Receptors (TCR) |
-Recognize antigen as a peptide bonded to an MHC class II molecule on the surface of an antigen presenting cell |
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Antigen Recognition by T cells |
-Each cell is clonally restricted -Each cell expresses a receptor able to react to a given peptide -Each cell can only recognize a limited number of antigens |
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Functions of Activated T cells |
-Proliferation -Differentiation -Production of cytokines -Development of effector function |
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Helper T Cells (Th Cells) |
-CD4+ effector cells -Includes Th1, Th2, and Treg cells |
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Th1 Cells |
Cell-mediated effector mechanisms |
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Th2 Cells |
-Responsible for regulation of Antibody production |
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Treg Cells (Regulatory T cells) |
-Immunoregulatory cells |
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Cytotoxic T Cells (Tc Cells) |
-CD8+ -Destroy infected cells |
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Suppressor T Cells (Ts Cells) |
Downregulate actions of other T and B cells (inhibits or dampens the immune response when the antigen has been destroyed) |
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B Lymphocytes (B cells) |
-Humoral Immunity (antibody-mediated) -Mature in the bone marrow -Lead to antibody production |
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Ig Receptors |
-B cell surface marker -Antibody molecule with antigenic specificity (B cells exists in the body with receptors specific for antigen) |
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Fc Receptor |
-B cell surface marker -Specifically binds to the Fc portion of the IgG antibody, may aid B cells in binding antigen already bound to antibody |
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B cell Characteristics |
-Demonstrate surface immunoglobulins (sIg) -Participate in secondary (anamnestic) response as memory cells -Differentiate into plasma cells with antigenic stimulation |
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B Cell Activation |
-Enlarge -Develop synthetic machinery -Divide -Mature -Secrete Antibody |
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Plasma Cells |
-Functions in the synthesis and excretion of immunoglobulins (Ab) -Arise at the end of B cell differentiation |
