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7 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Cholera |
bacteria releases cholera toxin that causes G protein to activate adenyl cyclase but cannot hydrolyze GTP so it is forever active; The cAMP build up leads to excessive secretion of water and electrolytes into the lumen |
severe form of diarrhea that can lead to rapid dehydration or death |
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Toxic thyroid noodles |
Rise from mutate G proteins that cannot hydrolyze GTP --> over production of camp in absence of TSH leading to over production of thyroid hormones and abnormal cell proliferation |
benign tumors derived from a single cell that proliferates abnormally |
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Whooping cough |
Bordella pertussis produces and secretes pertussis toxin which is internalized by cells of the upper respiratory tract --> locks Gia protein in inactive GDP bound state causing continous production camp |
acute inflammation of the upper respiratory tract that can cause paroxysmal coughing, inspiratory whoop, fainting/vomitting after cough |
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HER2 mutation |
mutated RTK, specifically HER2 EGFR induce proliferation signals in the absence of GF trastuzumab targets and inhibits HER2 Ras of Raf mutations can also contribute to unregulated cell proliferation |
Many human cancers (RTK) |
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tuberous sclerosis |
mutations in TSC2, a mTORC1 inhibitor, leads to development Deletion in PTEN would also cause cancer fyi |
causes benign tumors to grow in the brain and on other vital organs such as the kidneys, heart, eyes, lungs, and skin |
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Polycythemia Vera |
mutation in the gene that encodes JAK2 that is constitutively active even without EPO |
an abnormal increase in circulating RBCs that have no obvious external cause and is of neoplastic origin |
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Glucocorticoid clinical corellation |
VERY POWERFUL particularly for anti inflammatory and immunomodulatory action |
potential harmful action |
