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21 Cards in this Set
- Front
- Back
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signal input determines a cell's _________
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phenotype
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2 types of receptors:
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cell surface r,
intracellular r |
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not all aa can be P.
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true
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major aa to be P & targetted by p.atases
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ser, thr, tyr
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upon P, prot change their _____ and/or ____
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conformation
activity |
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desc signal. by GTP-BP
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prot binds GTP (active form) or GDP.
prot is not P. |
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ex of sig molec
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hormones
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receptors are linked with _______,______, or _____
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ion channel
g-prot enz |
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desc enz linked rec
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homo/hetero-dimer receptor can be enz or recruit one
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kinases dont have to be prot. can be _______.
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lipids
(phospholipid/phosphoprot) |
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how does a recep recruit prot?
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phosphorylated regions serve as docking sites
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______ domain binds inositol phospholipid
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PH
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______ domain binds p Y
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SH2, PTB
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_______ binds _____ rich region
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SH3 - proline
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synthesize cAMP by ________ from _________
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adenylyl cyclase
ATP |
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degrade cAMP by ___________ into ________
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cAMP phosphodiesterase
(no change in phosphorylation) 5'AMP |
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cAMP's major target is
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PKA
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PKA's structure
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2 regulatory, 2 catalytic
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gene transcription activ leading to [cAMP]
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GPCR -> activated alpha G-prot -> adenylyl cyclase (membrane bound, FA side chain) -> (ATP sheds PP = cAMP)
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cAMP activates PKA which goes into _____ and activates _______ which then activates the ____ for transcription.
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the nucleus
CREB (Transc F) gene |
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PPI
permanent AKA ______ |
obligate
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