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21 Cards in this Set

  • Front
  • Back
signal input determines a cell's _________
phenotype
2 types of receptors:
cell surface r,
intracellular r
not all aa can be P.
true
major aa to be P & targetted by p.atases
ser, thr, tyr
upon P, prot change their _____ and/or ____
conformation

activity
desc signal. by GTP-BP
prot binds GTP (active form) or GDP.

prot is not P.
ex of sig molec
hormones
receptors are linked with _______,______, or _____
ion channel
g-prot
enz
desc enz linked rec
homo/hetero-dimer receptor can be enz or recruit one
kinases dont have to be prot. can be _______.
lipids

(phospholipid/phosphoprot)
how does a recep recruit prot?
phosphorylated regions serve as docking sites
______ domain binds inositol phospholipid
PH
______ domain binds p Y
SH2, PTB
_______ binds _____ rich region
SH3 - proline
synthesize cAMP by ________ from _________
adenylyl cyclase

ATP
degrade cAMP by ___________ into ________
cAMP phosphodiesterase
(no change in phosphorylation)

5'AMP
cAMP's major target is
PKA
PKA's structure
2 regulatory, 2 catalytic
gene transcription activ leading to [cAMP]
GPCR -> activated alpha G-prot -> adenylyl cyclase (membrane bound, FA side chain) -> (ATP sheds PP = cAMP)
cAMP activates PKA which goes into _____ and activates _______ which then activates the ____ for transcription.
the nucleus

CREB (Transc F)

gene
PPI

permanent AKA ______
obligate