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15 Cards in this Set
- Front
- Back
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What are the causes of cell injury?
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What is the first manifestation of cellular injury common to all
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Cellular swelling
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What are the ultrastructural changes associated with reversible cell injury?
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Plasma villi alterations
Mitochondrial changes Dilatation of the ER Nuclear alterations |
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What are the patterns of tissue necrosis?
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Coagulative necrosis
Liquefactive necrosis Gangrenous necrosis Caseous necrosis Fat necrosis Fibrinoid necrosis |
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What are the consequences of loss of ATP?
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Na pump failure
Increased anaerobic glycolysis Detachment of ribosomes - reduction in protein synthesis Failure of Ca pump Unfolded protein response |
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What is the consequence of Na pump failure?
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Cell swelling
Dilatation of the ER |
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What is the consequence of increased anaerobic glycolysis?
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Acidosis
Protein denaturation |
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What is the consequence of mitochondrial damage?
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Opening of permeability transition pore
Caspase activation |
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What are the consequences of increased intracellular calcium?
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Permeability transition pore opens
Phospholipase, protease, endonucleases, APTases induction of apoptosis |
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What are the free radicals involved in cellular injury?
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.O2
H2O2 .OH ONOO- |
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How are free radicals generated?
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redox
UV inflammation metabolism of chemicals transition metals NO |
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How are free radicals removed
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How are free radicals damaging?
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What are the mechanisms of membrane damage?
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Consequences of membrane damage?
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