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21 Cards in this Set

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  • Back
Defense against ingested microbes
Th1 cells
Defense against infected cells with microbes in cytoplasm
CTLs
Anatomical site of activation of naive T cells
Lymphoid organs
Anatomical site of antigen elimination by effector T cells
Peripheral tissues
Homing molecules on activated T cells
E- and P-selectin ligand, LFA-1 or VLA-4, CXCR3
Homing molecules on naive T cells
L-selectin, LFA-1, CCR7
Immune-mediated tissue damage
Hypersensitivity
Effector cell of delayed-type hypersensitivity (DTH)
Macrophage
Major cytokine that activates macrophages to kill ingested microbes
IFN gamma
Skin test that detects DTH response to Mycobacteria
PPD
Time frame to elicit a DTH reaction
24-48 hours
Mechanisms of damage in DTH
Macrophages, CTLs, granulomatous inflammation
Chronic CMI response to TB
granulomas
Defense against helminth infections
IgE and IL-5-activated eosinophils
Enzymes that cleave and activate caspases
Granzymes
Protein necessary for delivery of granzymes into target cells
Perforin
Mechanism of CTL-mediated killing of target cell
Apoptosis
Cytokines that inhibit microbicidal activity of macrophages
IL-4, IL-10, IL-13
Activating signals for CTLs
Antigen recognition & firm adhesion
Viral-induced mechanism of immune evasion
Inhibit antigen presentation
Mycobacteria-induced mechanism of immune evasion
Inhibit phagolysosome fusion