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29 Cards in this Set
- Front
- Back
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Intracellular location of phagocytized microbes
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Vesicles (phagolysosome)
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Location of most intracellular pathogens that have invaded cells
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Cytoplasm
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T cell accessory molecule that binds co-stimulators
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CD28
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T cell accessory molecule involved in negative regulation of activated T cells
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CTLA-4
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APC molecule that provides second signal to T cells
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B7
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T cell accessory molecules involved in signal transduction
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CD4, CD8, CD3 & (zeta)
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T cell accessory molecules involved in adhesion
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LFA-1 and VLA-4
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Substances that induce expression of co-stimulators on APCs
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Adjuvants
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Autocrine cytokine that promotes T cell proliferation
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IL-2
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Region of contact between APC and T cell
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Immunologic synapse
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Anatomical site of activation of T cells by APCs
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Paracortex of lymph nodes
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Tyrosine motifs on CD3 and chains involved in signaling
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ITAMs
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Tyrosine kinase that triggers several signaling pathways
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ZAP-70
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High affinity version of the IL-2 Receptor
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IL-2R alpha/beta/gamma c
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T cell population that defends against intracellular microbes
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Th1
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Cytokines that drive development of Th1 cells
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IL-12, IFN gamma
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Signature cytokines of Th1cells
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Interferon- gamma TNF, IL-2
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T cell population that defends against extracellular microbes
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Th2
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Cytokine that drives development of Th2 cells
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IL-4
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Signature cytokines of Th2 cells
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IL4, IL-5, IL-13
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T cell population involved in inflammatory disorders
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Th17
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Signature cytokines of Th17
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IL-17, IL-22
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Cytokine that inhibits T cell activation
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TGF beta
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Cytokine that induces B cell switching to produce IgE
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IL-4
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Cytokine that activates eosinophils
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IL-5
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T cell population that drives activation of macrophages and production of some classes of antibodies
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Th1
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T cell population that drives production of some classes of antibodies
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Th2
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T cell population that directly kills infected cells
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CTLs
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Ligand expressed on CD4+ T cells that makes APC better at stimulating T cells
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CD40L
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