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13 Cards in this Set
- Front
- Back
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Catalase
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Changes H2O2 to H20
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Superoxide Dismutases
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Convert Superoxide to H2O2
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Glutathione Peroxidase
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Converts H2O2 to H20 and GSH to GSSG
Important aspect of the cells abilty to detoxify reactive oxygen species |
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Coagulative Necrosis
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When denaturation is the primary pattern
Hypoxix death of all cells except the brain Preservation of the basic outline of the cell |
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Liquefactive Necrosis
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Dominant enzyme digestion
Hypoxic death of cells within the CNS Completly digests the dead cells |
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Caseous Necrosis
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Often associated with tuberculous infection
Caseous means cheesy white appearance Form of coagulative necrosis but the border is obliterated |
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Fat Necrosis
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Associated with pancreatitis
Leak of pancreatic enzymes that break down fat in the peritoneal cavity Form Calcium soap deposits |
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Which would injure a tissue faster hpoxia or ischemia?
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Ischemia b/c it also prevents the delivery of nutrients necessary for glycolysis
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Ischemic Injury
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Associcated with inflammation
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How does the complement pathway relate to ischemic-reprofusion injury?
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IgM deposit more in ischemic tissue and when blood flow is resumed proteins bind to the antibodies and cause cell injury and inflammation
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How is acetaminophen metabolite detoxified?
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By the interaction with GSH after is was converted into a toxic metabolite by C P450
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Dystrophic Calcification
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Deposition of calcium salts in DYING tissues (necrosis)
Occurs despite NORMAL serum levels of Ca2+ Absence in Ca2+ metabolism |
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Metastic Calcification
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Depostition of calcium salts in NORMAL tissue
Results from hyperccalcemia Some disturbence in Ca2+ metabolism Increased secretion of PTH Hyperparathyrodism, vitamin D disorders, Renal Failure |
