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10 Cards in this Set
- Front
- Back
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What is zygote like?
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Totipotent, potential to become any cell in the body or placenta
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What is stem cell like?
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It can divide to renew themselves indefinitely.
-> Multipotent or Unipotent |
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Steps of Apoptosis
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1) The nucleus begins to break apart DNA into smaller pieces, organelles in blebs
2) The cell break into several apoptotic bodies. The organelles are still functional |
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Stages of Necrosis
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1) Structure of nucleus changes
2) Blebs fuse and become larger -> No organelles in blebs 3) The cell membrane ruptures & releases the cell's content. Organelles are not functional. |
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What is an intrinsic pathway of apoptosis?
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Due to chemical/IR -> Oxidative stress
- Involves activation of Bax, Apaf-1 which leads to activation of caspase 9 |
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What is activated in extrinsic pathway of apoptosis?
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Fas/FasL which activates caspase 8
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Where are the stem cell populations?
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Skin
Hair Gut Bone Muscle Neuronal (Some stem cell capacity) |
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2 types of stem cell division
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Symmetric & Asymmetric
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What is the difference between symmetric and asymmetric divisions?
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Symmetric: Self-renewal/Differentiation
Asymmetric: 1 daughter cell remains a stem cell, the other becomes committed to terminal differentiation |
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What is cell senescence
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Irreversible proliferative arrest
-Function as a self-defence mechanism to prevent proliferation of potentially damaged cells |
