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3 Cards in this Set
- Front
- Back
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What molecular events happen...
1. before G1 2. Before M 3. Before S |
1. complete cell division: trigger anaphase and proceed to cytokinesis
2. assemble mitotic spindle 3. replicate DNA |
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1. What is MPF and what is it composed of?
2. How does Cdk get activated? |
1. Maturation Promoting Factor: composed of Cyclin + Cdk
2. Cyclin bind to Cdk, revealing activation loop --> CAK phosphorylates ser/thre/tyr sites |
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Describe the pathway where Rb regulates G1 --> S transition
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Rb sequester E2F
--> CyclinD-Cdk4/6 phosphorylates Rb --> Cyclin E-Cdk2 hyperphosphorylates Rb --> E2F released --> E2f promotes transcription of cyclin e and A --> cyclin E binds to Cdk 2, which together activates cyclin A-Cdk2 --> then replication initiation proteins are phosphorylated to start DNA synthesis |
