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19 Cards in this Set
- Front
- Back
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what are the 4 major families of adhesion molecules?
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1. cadherins
2. immunoglobin superfamily 3. integrins 4. selectins |
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what are cadherins critical during?
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development, tissue formation
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what do cadherins require for binding?
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Ca2+
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what family of cell adhesion molecules do pathogens exploit for spreading?
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cadherins
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what family of cell adhesion molecules are glycoproteins?
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integrins
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what do integrins do?
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mediate cell-cell and cell-matrix interactions
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describe the structure of integrins.
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heterodimers with at least 8 B and 15 a sub-units
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what do selectins do?
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carbohydrate-binding proteins that mediate the initial attachment of flowing leukocytes to the blood vessel wall in inflammatory responses
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what are immunoglobins built from?
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tightly packed barrel of B strands
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what are immunoglobins important for?
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leukocyte migration through endothelium for firm adhesion and diapedesis
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what are the 3 functions of the extracellular matrix?
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1. support
2. shock absorption 3. holds structure together |
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what is the extracellular matrix?
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intricate meshwork of interacting, extracellular macromolecules
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what adds strength to the ECM?
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collagen fibres
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is collagen a fibrous or globular protein?
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fibrous
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describe the structure of collagen
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triple helical made of 3 a chains wound around eachother
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what stabilizes the collagen helix?
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protein side chains of glycine point into centre
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what are glycosaminoglycans?
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long unbranched polysaccharide chains
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what are proteoglycans?
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glycoproteins containing covalently linked GAGs
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what are MMPs involved in?
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cell signalling, tissue degradation etc
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