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11 Cards in this Set
- Front
- Back
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Positive Amino Acids |
Arginine, Arg, R Lysine, Lys, K Histidine, His, H |
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Negative Amino Acids |
Aspartic Acid, Asp, D Glutamic Acid, Glu, E |
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Uncharged Polar |
Asparagine, Asn, N Glutamine, Gln, Q Serine, Ser, S Threonine, Thr, T Tyrosine, Tyr, Y |
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Nonpolar |
Alanine, Ala, A Glycine, Gly, G Valine, Val, V Leucine, Leu, L Isoleucine, Ile, I Proline, Pro, P Phenylalanine, Phe, F Methionine, M Tryptophan, W Cysteine, C |
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Protein to Protein binding Methods |
Surface- String Helix-Helix Surface-Surface |
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BARSTAR! stops who? |
Barnase |
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Common PTMs (covalent) |
-phosphate on Ser,Thr, or Tyr -methyl on Lys -acetyl on lys -Palmityl group on Cys -N-acetyglucosamine on Ser or Thr |
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Phosphorylation is an example of? |
A covalent post translational modification. |
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Retinal |
is a type of Vitamin A that binds to opsin proteins |
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Ubiquitination and types |
The addition of ubiquitin C terminus bound to Lys residue of substrate Mono-Ub: endocytosis, protein transport, DNA repair, and histone regulation Multi-Ub: endocytosis Poly-Ub K63: endocytosis, DNA repair, and signaling Ploy-Ub K48: proteasomal degradation |
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examples of multiple modification regulations |
Src Kinase:Removes phosphate->activates ligand that binds to SH3 domain-> kinase phosphorylates tyrosine to self activate. P53: causes DNA damage, hypoxia, heat/cold shock, mitotic spindle damage.-> leads to Cell cycle arrest, DNA repair, Apoptosis, Senescence |
