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8 Cards in this Set
- Front
- Back
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What signal does an endothelial cell use to cause a neighboring smooth muscle cell to relax?
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Nitric Oxide
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what ligand binds to the GPLR to trigger NO synthase?
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acetylcholine
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what is the pathway from ligand to NO reaching a neighboring smooth muscle cell?
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Acetylcholine--> GPLR--> IP3--> ER--> Ca2+--> Calmodulin--> NOsynthase--> NO--> neighboring cell
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what chemical does NOsynthase use to make NO and what are the end products?
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Arginine --> NO + Citrulline
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What is Arginine converted into after a GPLR is triggered by acetylcholine?
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NO + citrulline
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What is activated in a smooth muscle cell by NO?
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Guanylyl cyclase
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what does activated guanylyl cyclase do?
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GTP --> cGMP +PPi
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what is the signaling pathway in a smooth muscle cell from NO to vasodilation?
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NO--> Guanylyl cyclase--> cGMP--> Protein Kinase G--> smooth muscle relaxation--> vasodilation
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