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43 Cards in this Set

  • Front
  • Back
tubulin
protein that makes up microtubules
actin
protein that makes up microfilaments
video microscopy
technique used to follow activites of molecular motors
protofilaments
row of globular subunits of a microtubule
plectin
protein connecting microtubules and neurofilaments. connects the different filaments to each other as a cross bridge
kinesin
motor protein that moves to (+) end - Plasma Membrane or ER
KIF5B
Kinesin like protein that transports mitochondria outward.
cytoplasmic dyneins
(-) end directed microtubular motor.
centrosome
animal's microtubule organizing center (MOC). Consists of two barrel shaped centrioles surrounded by a peri-centriolar material. (PCM)
regrowth of MTs
addition of subunits at the (+) end of the polymer away from the centrosome
nucleation of MTs
alpha and beta tubulin dimers bind to open ring of gamma tubulin.
Colchicine, Vinblastine, Vincristine, Nocadazole, Ca ions, and Cold Temperatures
MT Destabilizers. Binds dimers and prevents assembly into + end.
Taxol
MT Stabilizer. Binds alongside of polymer and prevents disassembly.
Internal Structure of Cilium
central microtubule, central sheath, radial spoke, outer doublet, cilium and basal body.
Intraflagellar Transport (IFT)
assembles and maintains ciliary region.
Keratin I & II
IF protein found in epithelia
Vimentin
IF protein found in mesenchymal cells
Desmin
IF protein found in muscle cells
Glial fibrillary acid protein
IF protein found in glial cells
Peripherin
IF protein found in astrocytes
Neurofilament Proteins
IF proteins found in nuerons of the central and peripheral nervous system.
Lamin Proteins
IF proteins found in cells with lamin A,B,C in nuclear envelope
nestin
IF proteins found in neuronal stem cells
myosin
molecular motor for actin filaments
Conventional (Type II) myosins
found in various muscle and non muscle cells. in non muscle functions it splits cell in two during cytokinesis and generates tension at focal adhesions.
Myosin Va
specific myosin motor that transports vesicles in cooperation with either a kinesin of dynein motor protein.
Z line of Sarcomere
borders of the sarcomere
A Band
The full thick filament
I band
Just the thin filament that is not overlapped by thick filament
H zone
Middle of thick fil
tropomyosin
rod-shaped molecule situated in the grooves of thin filaments. When moved, it exposes the binding site on the thin filament to the myosin head.
troponin
molecules spaced at defined intervals in a thin filament. Interacts with calcium to to move tropomyosin and expose the binding site on the thin filament to the myosin head.
titin
from z line to the m band. Maintains the thick filaments in the center during contraction
nebulin molecules
acts as a molecular ruler regulating the number of actin monomers allowed to assemble into a thin filament.
microvilli
present on apical surface of epithelia (lining of kidneys and intestines) and absorbs solutes.
villin
bundling protein that arranges actin filaments in microvilli
fimbrin
bundling protein that arranges actin filaments in microvilli
myosin I
located between plasma membrane and actin filaments. its purpose is unknown.
lamellipodium
portrusion shape of leading edge of cell
Arp 2/3 complex
Is activated in the mechanism for movement of a non-muscle cell and initiates the nucleation of actin polymerization. Then anchors to actin and pushes them outward causing Plasma membrane to extend outward.
WASP family
activates the Arp 2/3 complex in non-muscle cell movement
colifin
binds to ADP-actin subunits causing depolymerization. (specifically in mechanism for non-muscle cell movement)
prolifin
free actin subunits bind to it and get recharged by ATP/ADP exchange making them ready for actin polymerization. (specifically in mechanism for non-muscle cell movement).