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43 Cards in this Set
- Front
- Back
tubulin
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protein that makes up microtubules
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actin
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protein that makes up microfilaments
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video microscopy
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technique used to follow activites of molecular motors
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protofilaments
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row of globular subunits of a microtubule
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plectin
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protein connecting microtubules and neurofilaments. connects the different filaments to each other as a cross bridge
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kinesin
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motor protein that moves to (+) end - Plasma Membrane or ER
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KIF5B
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Kinesin like protein that transports mitochondria outward.
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cytoplasmic dyneins
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(-) end directed microtubular motor.
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centrosome
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animal's microtubule organizing center (MOC). Consists of two barrel shaped centrioles surrounded by a peri-centriolar material. (PCM)
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regrowth of MTs
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addition of subunits at the (+) end of the polymer away from the centrosome
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nucleation of MTs
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alpha and beta tubulin dimers bind to open ring of gamma tubulin.
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Colchicine, Vinblastine, Vincristine, Nocadazole, Ca ions, and Cold Temperatures
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MT Destabilizers. Binds dimers and prevents assembly into + end.
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Taxol
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MT Stabilizer. Binds alongside of polymer and prevents disassembly.
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Internal Structure of Cilium
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central microtubule, central sheath, radial spoke, outer doublet, cilium and basal body.
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Intraflagellar Transport (IFT)
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assembles and maintains ciliary region.
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Keratin I & II
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IF protein found in epithelia
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Vimentin
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IF protein found in mesenchymal cells
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Desmin
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IF protein found in muscle cells
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Glial fibrillary acid protein
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IF protein found in glial cells
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Peripherin
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IF protein found in astrocytes
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Neurofilament Proteins
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IF proteins found in nuerons of the central and peripheral nervous system.
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Lamin Proteins
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IF proteins found in cells with lamin A,B,C in nuclear envelope
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nestin
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IF proteins found in neuronal stem cells
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myosin
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molecular motor for actin filaments
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Conventional (Type II) myosins
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found in various muscle and non muscle cells. in non muscle functions it splits cell in two during cytokinesis and generates tension at focal adhesions.
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Myosin Va
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specific myosin motor that transports vesicles in cooperation with either a kinesin of dynein motor protein.
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Z line of Sarcomere
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borders of the sarcomere
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A Band
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The full thick filament
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I band
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Just the thin filament that is not overlapped by thick filament
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H zone
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Middle of thick fil
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tropomyosin
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rod-shaped molecule situated in the grooves of thin filaments. When moved, it exposes the binding site on the thin filament to the myosin head.
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troponin
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molecules spaced at defined intervals in a thin filament. Interacts with calcium to to move tropomyosin and expose the binding site on the thin filament to the myosin head.
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titin
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from z line to the m band. Maintains the thick filaments in the center during contraction
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nebulin molecules
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acts as a molecular ruler regulating the number of actin monomers allowed to assemble into a thin filament.
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microvilli
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present on apical surface of epithelia (lining of kidneys and intestines) and absorbs solutes.
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villin
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bundling protein that arranges actin filaments in microvilli
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fimbrin
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bundling protein that arranges actin filaments in microvilli
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myosin I
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located between plasma membrane and actin filaments. its purpose is unknown.
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lamellipodium
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portrusion shape of leading edge of cell
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Arp 2/3 complex
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Is activated in the mechanism for movement of a non-muscle cell and initiates the nucleation of actin polymerization. Then anchors to actin and pushes them outward causing Plasma membrane to extend outward.
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WASP family
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activates the Arp 2/3 complex in non-muscle cell movement
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colifin
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binds to ADP-actin subunits causing depolymerization. (specifically in mechanism for non-muscle cell movement)
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prolifin
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free actin subunits bind to it and get recharged by ATP/ADP exchange making them ready for actin polymerization. (specifically in mechanism for non-muscle cell movement).
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