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18 Cards in this Set
- Front
- Back
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Classes of Membrane lipids from most abundant to least
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1.Phospholipids
2. Spingolipids 3. Cholesterol 4. Eicosanoids |
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3 important types of Eicosanoids
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Important functionally
1. PGE2 2. TXA2 3. LTC4, LTD4, LTE4 |
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PGE2
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Prosteoglandins
induce uterine contractions platelet aggregation vasodilation |
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TXA2
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Thrombaxanes
platelet aggregation vasoconstriction |
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LTC4, LTD4, LTE4
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Induce vasodilation
Induce bronchioconstriction in asthma - - anaphalaxis |
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2 Diseases that involve fusiogenic property of phospholipids
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1. HIV
2. Measeles |
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4 Diseases that Involove Sphinolipid Metabolism
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1. Tay-sachs
2. Fabry's 3. Niemann-Pick 4.Gaucher's |
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Tay-Sachs
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Deficient E (DE) - Hexoaminidase A
Accumulating Enzyme(AE) - GM2 ganglioside |
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Gaucher's
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DE - Glucocerebrosidase
AS - Glucocerebroside |
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Fabry's
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DE - alpha-galactosidase A
AS - Ceramide |
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Niemann-Pick
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DE - Sphingomyelinase
AS - Sphingomyelin |
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4 factors affecting fluidity
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1. double bonds
2. heat 3. chain length 4. cholesterol |
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Disease Related to Cholesterol
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Walking Pneumonia
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Lipid Raft are important for
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1. signal transduction
2. endocytosis 3. Rapid re-organization of the membrane for extracellular matric modification and motility |
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Band - 3
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protein that is an anion exchanger in RBCs
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Hereditary Spherocytosis
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defective membrane interactions.
inherited Erthrocytes are spherical and cant get throught splenic sinus and gets eaten by macrophages =enlarged spleen (splenomegaly) Result = anemia |
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Carbohydrates on cell membrane are important for
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1. blood type antigens
2. pathogen recognition sites 3. reservoir for cytokines/growth factors |
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2 diseases involving pathogen recognition sites
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1. toxoplasmosis
2. Coccidiosis |
