Cell Bio: Tumor Genetics

Front 1

attributes of cancer cells?

Back 1

1) unregulated cell proliferation
2) invasion of other tissues
3) failure to die appropriately
4) reduction in ability to maintain DNA/chrom integrity
5) evasion of anti-tumor immunity

Front 2

how is cancer cell proliferation unregulated?

Back 2

escaped cell cycle control,
skip cell cycle checkpoints,
lose the requirement for extrinsic growth factors.

Front 3

how do cancer cells invade other tissues?

Back 3

loss of contact inhibition, metastasis, angiogenesis

Front 4

how do cancer cells avoid dying appropriately

Back 4

Loss or reduction in apoptosis response

Loss or reduction in ability to differentiate

Loss of response to telomere shortening - loss of senescence

Loss of response to DNA damage - cells don’t stop dividing, don’t die

Front 5

how do cancer cells have less of an ability to maintain geneic integrity?

Back 5

-Chromosome breakpoints, rearrangements, unrepaired mutations

-Genomic Instability - facilitates the sequence of changes in the development of cancer and the competition with neighboring cancer cells.