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12 Cards in this Set
- Front
- Back
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periplasm
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space in between cytoplasm and extracellular matrix in bacteria
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The Ca2+ -ATPase pumps?
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Ca2+ into intracellular storage compartments
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The Na+/K+ -ATPase mainstains?
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the plasma membrane Na+ and K+ gradients
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post-albers scheme
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proposes that an enzyme cycles between two fundamental conformations
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H+ - ATPase transports?
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protons out of the cytosol
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how do proteins enter the secretory pathway?
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by translocation
across the ER membrane. |
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What are the organelles in secratory pathway
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-endoplasmic reticulum
-golgi -late endosome -secretory vesicles -lysosomes -early endsome -cel curface |
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signal recognition particle (SRP)
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binds to the signal sequence of a protein when it is exposed to the cytoplasm
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binding of SRP to the signal sequence? So that ?
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slows down sequence
-the nascent protein is delivered to the ER still largely unsynthesized and unfolded -synthesis of nascent proteins does not outstrip the number of available translocation channels. |
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translocon
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is a protein complex that includes a gated protein channel that provides an aqueous passageway
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numerous accessory proteins associate with the tranlocon are involed with?
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translocation, folding, modification
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what drives posttranslational translocation?
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ATP hydrolysis by the BiP protein with in the ER lumen.
-bip bind to nascent chain, preventing it from slipping back out the channel |
