Cell 6.4

Front 1

What is the EARLY PHASE of would healing?

Back 1

Hemostasis and Inflammation

platelet activation and aggregation and coagulation release mediator of inflammation

inflammation attracts cellular element and allows exudation of plasma proteins into wound

neutrophils arrive (not necessary for normal wound healing)

Front 2

True or False

Are neutrophils necessary for normal wound healing?

Back 2

True

Front 3

What are the 3 parts of Intermediate Phase of wound healing?

Back 3

Wound Contraction

Regeneration

Repair (scarring)

Front 4

During wound healing what helps in contraction of the of the wound?

Back 4

Myofibroblasts

Front 5

Term used to describe REPLACEMENT of destroyed tissue by the same type of tissue.

Back 5

Regeneration

Front 6

What type of tissues are able to routinely/continuously divide and regenerate?

Back 6

Labile Tissues

Front 7

What type of tissues are able to regenerate if stimulated?

Back 7

Stable (QUIESCENT) Tissues

Front 8

What type of tissues are NOT able to regenerate after injury?

Back 8

Permanent (NON-DIVIDING) Tissues

Front 9

? contributes to directing CELL POLARITY and ORDERLY REGROWTH during regeneration in wound healing

Back 9

Basement Membrane

Front 10

Replacement by fibrous connective tissue during wound healing is called ?

Back 10

Repair (Scarring)

Front 11

What are the 4 general steps of ANGIOGENESIS?

Back 11

Degradation of parent vessel basement membrane

Migration of endothelial cells toward the angiogenic stimulus

Proliferation of endothelial cells behind leading front of migrating cells

Maturation of endothelial cells, organizing into capillary tubes

Front 12

? and ? proliferate and migrate into a wound under stimulation of growth factors and cytokines from Macrophages and Endothelial cells.

Back 12

Fibroblasts

Myofibroblasts

Front 13

? and ? are IMPORTANT contributors to directed cell migration.

Back 13

Fibronectin

Laminin

Front 14

What are the extracellular matrix components that fibroblasts secrete?

Back 14

Fibronectin

Hyaluronan

Collagen I and III

Front 15

During the EARLY part of Wound Repair--

What are the Extracellular Matrix Depositions?

Back 15

FIBRONECTIN - provides "scaffold" for cell migration into wound


HYALURONIC ACID - provides hydration and tissue turgor

Front 16

During the LATER part of Wound Repair--

what are the Extracellular Matrix Depositions?

Back 16

COLLAGEN - tensile strength, seen 4 days after injury

--> Type III Collagen made FIRST

--> Type I Collagen made LATER

Front 17

What is the hallmark of early wound healing?

proliferating small vessels and fibroblasts with loose delicate CT background

Back 17

Granulation Tissue

Front 18

During what Phase of wound healing is Scar Formation and Remodeling seen in?

Back 18

Maturation (remodeling) phase

Front 19

Wound strength is dependent on ? which takes about 2 months to completely form.

Back 19

Type I Collagen

Front 20

What is PRIMARY UNION or HEALING by FIRST INTENTION?

Back 20

a clean uninfected surgical incision

Front 21

What is Secondary Intention?

Back 21

large and/or irregular and/or infected wound

Front 22

Granulation tissue is rich in ?

Back 22

mucopolysaccharide hyaluronic acid

(mucopolysccharides = glycosaminoglycans)

Front 23

What are the multiadhesive proteins that are deposited early in wound healing called?

where do they come from--
Early?
Later?

Back 23

Fibronectin

Plasma derived

endothelium, monocyte, fibroblast, etc.

Front 24

What cells are the MAJOR producers of collagen and collagenases?

Back 24

Fibroblasts

Front 25

Produces cytokines and growth factors

"orchestrator" cell of wound healing

Back 25

Monocyte / macrophage

Front 26

ECM proteins (fibronectin etc.) have ? that attaches to CELL INTEGRINS influencing cell locomotion, proliferation, and differentiation

Back 26

RGD motif

Front 27

cellular contribution to cell migration into wounds includes adhesion molecules such as ? which bind to RGD sequences found on many ECM proteins

Back 27

INTEGRINS

Front 28

Multifunctional growth factor that regulates other cytokine/growth factors that are involved in repair

ex: PDGF, FGF, TNF, IL-1

Back 28

TGF-β

transforming growth factor - β

Front 29

Stimulates proliferation of epithelial cells and fibroblasts

Back 29

Epidermal Growth Factor (EGF)

Front 30

stored in PLATELET GRANULES and other cells

--released at site of injury

causes migration and proliferation of fibroblasts, smooth muscle, and monocytes

Back 30

Platelet - Derived growth factor

PDGF

Front 31

Induces Angiogenesis

(2 factors)

Back 31

Basic Fibroblast Growth Factor (bFGF)


Vascular Endothelial Growth Factor (VEGF)

Front 32

Promotes inflammation, cell migration and fibroblast proliferation

Stimulates production of both COLLAGEN and COLLAGENASES by fibroblasts

Back 32

IL-1

TNF

Front 33

What vitamin is necessary for good healing?

? is a cofactor in the metallocollagenases necessary for collagen remodeling.

Back 33

Vitamin C


Zinc

Front 34

? inhibits phospholipases and thus limits the production of inflammatory mediators produced by metabolism of ARACHIDONIC ACID

-reduced inflammation
-reduced collagen production

Back 34

Corticosteroids

Front 35

Non-healing ulcerations are usually associated with inadequate ?

Back 35

inadequate blood supply

Front 36

Wound DEHISCENCE is commonly associated with what 3 things?

Back 36

infection

Vitamin C deficiency

mechanical stress (vomiting)

Front 37

Raised, reddened, may be pruritic (itchy), BUT IT REMAINS IN BOUNDARIES OF THE SCAR

Back 37

Hypertrophic Scar

Front 38

abnormal overgrowth of scar tissue that mushrooms over the edges of the wound

Back 38

Keloid (a progressive scar that tends to recur)