Cell 3.2 :: Incomplete

Front 1

True or False

Only EFFERENT lymph vessels are present in diffuse lymphatic tissue.

Back 1

True

Front 2

Lymph nodules

What do primary nodules lack?

Back 2

lacks GERMINAL CENTER

(does not have a pale center)

Front 3

What are secondary nodule (lymph nodules) ?

Back 3

has a GERMINAL CENTER (pale zone)

lymphocytes (lymphoblasts) are present
follicular dendritic cells

small lymphocytes make mantle and marginal zone (making it dark)

found in lymph nodes, spleen, MALT

INFLAMMATORY OR ANTIGENIC STIMULATIOn

Front 4

Where are secondary nodules found?

Back 4

wherever there is inflammatory or antigenic stimulus.

Front 5

Where are postcapillary venules found in a lymph node?

what type of endothelium do they have?

Back 5

Present in the paracortex (deep cortex)

High endothelial venules (HEV)

Front 6

What is the site where T-lymphocytes leave the blood circulation and enter the lymphatic circulation?

Back 6

High endothelial venules (HEV)

Front 7

Where is the T-lymphocyte dependent zone in a lymph node?

Back 7

Paracortical

Front 8

Lymphocytes exit lymph nodes via ? lymph vessels.

Back 8

Efferent

Front 9

What cells are found mainly in the cortex of lymph nodes?

Back 9

B-lymphocytes

Front 10

What cells are found in the paracortex (inner cortex) of lymph nodes?

Back 10

T-lymphocytes

Front 11

What cells are found in the medullary cords of lymph nodes?

Back 11

B-lymphocytes

Plasma Cells

Front 12

? are present as part of the sinus wall and in the stroma.

They are specialized fibroblasts that produce ? collagen forming lymph node stroma.

Back 12

Reticular Cells

produce TYPE III Collagen

Front 13

True or False

Reticular cells have surface markers and produce cytokines that attract lymphocytes and dendritic cells.

Back 13

True

Front 14

? cells are bone marrow derived APC

present in the paracortex (deep cortex)

involved in antigen presenting to T-lymphocytes

Back 14

Dendritic Cells

(aka Interdigitating Dendritic Cells)

Front 15

? reside in the follicles and have long cytoplasmic processes to which antigen-antibody complexes adhere.

Back 15

Follicular Dendritic Cells

FDC

Front 16

True or False

Follicular Dendritic Cells are APC's and are able to present antigen to B-lymphocytes.

Back 16

FALSE

Follicular dendritic cells are NOT antigen presenting but are able to help B-lymphocyte proliferation

Front 17

Macrophages are found in most regions of a lymph node but are most prominent in ?

Back 17

Germinal Centers

Front 18

True or False

Thymus is made up of paired lobes subdivided into lobules.

It has a thin capsule with incomplete septa.

Back 18

True

Front 19

What cells are found in the cortex of the thymus?

Back 19

lymphocytes undergoing selection, differentiation, and maturation

thymic epithelial cells

macrophages

Front 20

Thymic epithelial cells have ? and ? that link them together.

Back 20

Desmosomes

Tonofibrils (keratin intermediate filaments)

Front 21

True or False

COrtical Epithelial cells express MHC I and II

Back 21

True

Front 22

What are the Cortical Epithelial Cells?

Back 22

Subcapsular Epithelial cells

Nurse Cells / Inner Cortical Epithelial cells

Front 23

? cells have TIGHT JUNCTIONS and participate in BLOOD-THYMUS barrier.

Back 23

Subcapsular Epithelial Cells

Type I thymic epithelial cells

Front 24

? cells form an interconnected network and partially surround developing thymocytes providing a specialized microenvironment.

Back 24

Nurse cells / Inner Cortical epithelial cells

Type II thymic epithelial cells

Front 25

? cells are at the interface of cortex and medulla and participate in controlling transition of developing thymocytes between medulla and cortex.

Back 25

Type III Thymic epithelial cells

Type IV Thymic Epithelial cells

Front 26

? cells form an extensive cell processes for a network (reticulum) that express MHC I and II

Back 26

Medullary Epithelial cells

Type V thymic epithelial cells

Front 27

? are made up of flattened concentrically-oriented KERATINIZING epithelial cells (form round balls of keratinizing cells) and DO NOT express MCH II

Back 27

Hassall's Corpuscles

Type VI Thymic Epithelial cells

Front 28

Where are T-cells developed into immunologically competent T Cells?

Back 28

Thymus

Front 29

What humoral factor does the thymus produce which affects the maturation of lymphocytes in other lymphatic organs?

Back 29

Thymosin

Front 30

What is the largest single lymph organ in the body?

Back 30

Spleen

Front 31

True or False

The spleen has lymph sinuses and afferent lymph vessels.

Back 31

FALSE

ONLY HAS EFFERENT LYMPH VESSELS!!!!!

Front 32

? covers the spleen made up of ? cells

Back 32

Peritoneum

Mesothelial Cells

Front 33

? and ? cells form a stroma throughout the spleen.

Back 33

Reticular Fibers

Reticular Cells

Front 34

White pulp in the spleen is DARK BLUE due to the large number of lymphocytes.

? arteries are present and are surrounded by a ?

What cells are found along the sheath?

What cells are found at the nodules?

Back 34

Central Arteries (follicular arteries)

surrounded by a PERIARTERIAL LYMPHOCYTIC SHEATH (PALS)

T-lymphocytes --PALS

B-lymphocytes --Nodules

Front 35

Red pulp (75% of spleen) consists of ? cords and ? sinusoids.

The cords contain many ? and ?

Back 35

Splenic Cords (Billroth Cords)

Venous Sinusoids

RBC and Macrophages

Front 36

? are the larger arteries found in the fibrous trabeculae of the spleen.

Back 36

Trabecular Arteries

Front 37

? are surrounded by the PALS and lymph nodules.

Back 37

Central Arteries in white pulp

Front 38

? are branches of the central arteries and the ends are ensheathed by a layer of ? ? and ? cells.

the ends are called ARTERIAL CAPILLARIES

Back 38

Penicillar (straight arteries)

Macrophages
Reticular Cells
Lymphatic Cells

Front 39

Describe the open and closed circulation theories of the spleen.

Back 39

Open theory - has the arterial capillaries emptying into SPLENIC CORD SPACES. Then blood is passed between endothelial cells of the sinusoids to get back into circulation.

Closed theory - blood always remains within a channel lined with endothelium and terminal arterial capillaries open directly into the venous sinusoids.

Front 40

Describe Venous Sinusoids.

Back 40

Elongated endothelial cells

after venous sinusoids --> blood courses to pulp (connecting) venules and veins which enter the trabecular veins

Front 41

What is the function of the spleen?

Back 41

Filters blood

produce lymphocytes with B-cells producing antibodies

destroy worn out RBC

hematopoiesis in embryo

Blood storage

Front 42

? are lymphoid tissues associated with 'wet' epithelia.

Back 42

Mucosal Associated Lymphoid Tissue (MALT)

Front 43

Name examples of different MALT?

Back 43

Tonsils

GALT (gut associated)
Peyer's Patch
Vermiform Appendix

BALT (bronchial associated)

Front 44

True or False

Tonsils are covered with mucosa and consists of aggregates of nodules with EFFERENT lymph vessels only.

Back 44

True

Front 45

Tonsils are MALT organs and are part of a collection of MALT tissues collectively called ? because they are in a ring-like arrangement around the superior portion of the pharynx

Back 45

Waldeyer's Ring

Front 46

What are the the MALT tissues that make up the Waldeyer's ring?

Back 46

Palatine Tonsils

Lingual Tonsils

Pharyngeal Tonsils

Front 47

? have pseudostratified columnar epithelium and focally squamous mucosa that covers the surface.

Back 47

Pharyngeal Tonsils

aka ADENOID

Front 48

? are surrounded by tongue muscles and are buried in the posterior tongue.

Back 48

Lingual Tonsils

Front 49

Largest tonsil and is covered with stratified squamous NON-KERATINIZED epithelium.

Back 49

Palatine Tonsils

Front 50

REMEMBER

Nodules only have EFFERENT lymph.

while

Nodes have both EFFERENT and AFFERENT lymp.

Back 50

REMEMBER

Nodules only have EFFERENT lymph.

while

Nodes have both EFFERENT and AFFERENT lymp.