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17 Cards in this Set
- Front
- Back
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Regardless of the isotype, ALL 5 classes of Ab are a result of epitope recognition by ? and ?.
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sIgM
sIgD |
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Describe the steps in B-cell activation.
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Cross-Linking of BCR with Ag
=> Igα and Igβ initiate intracellular signaling pathways => T helper cell delivers 2nd signal via CD40L and cytokines |
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How many subisotypes/subclasses are there of IgG?
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4 subisotypes
IgG1 (predominant subclass) IgG2 IgG3 IgG4 |
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True or False
In Subisotypes, the Variable Regions of the paratopes do NOT differ from each other. |
True
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What distinguishes the 4 subclasses of IgG from each other?
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amino acid variations within the HINGE REGION
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What is the only Ab class capable of crossing the PLACENTA?
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IgG
note: IgG2 is the least efficient in crossing |
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Placental cells express a PROTECTION RECEPTOR called ? that enables IgG to cross the placenta via the Fc portion.
Similar to MHC Class I |
FcRn
aka BRAMBELL Receptor |
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The term for clumping of insoluble Ag
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agglutination
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the term used for clumping of soluble Ag
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Precipitation
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True or False
IgG is capable of AGGLUTINATION and PRECIPITATION |
True
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Term that is described as IgG binds Ag and facilitates phagocytosis via the Fc binding to receptors on PMNs and other cells.
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Opsonization
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When Ab Fc binds to a NK cell, it is then termed an ?
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Antibody-Dependent Cell-mediated Cytotoxic Cell (ADCC)
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What are the 5 major functions of IgG?
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ACTIVATES complement
NEUTRALIZES toxins and viruses IMMOBILIZES motile bacteria OPSONIZATION (coating bacteria for phagocytosis) |
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IgA is found in serum as a ? and in SECRETIONS as a ?
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monomer = serum IgA1
dimer = secretions IgA2 |
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IgA2 is a dimer joined by a ?
Cystein-rich |
J Chain
(joining) |
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True or False
IgA activates complement |
FALSE
it DOES NOT activate complement |
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What is the Antibody that is efficient ANTIVIRAL Ab that prevents viruses from entering host cells.
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IgA
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