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289 Cards in this Set

  • Front
  • Back

Endocrinology

Study of the endocrine system. It covers the activities and structures of the system in health and disease

Homeostasis

Internal conditions are maintained

Tissuea that detect internal change


Tissues that synthesize hormones


Hormones


Target tissues that responds to hormonal sign

Components of the endocrine system

Glands


Heart


Fat tissue


Liver

Tissues that synthesize hormones

Pituitary


Thyroid


Parathyroid


Adrenal


Pancreatic


Gonads

Classic endocrine glands

Negative feedback

Stimulus that perturbs balance is corrected by initiating a physiologic response that opposes the stimulus

Positive feedback

Event/stimulus is amplified by the endocrine system to facilitate and complete a task

Peptide hormones

Are made up of amino acids. They are encoded by genes in the cells that synthesize them. These genes are responsive to long term and short term regulation

Steroidal hormones

Are derived from further processing of membranes cholesterol. Concentration pressure and enzyme activity regulate the levels of these hormones

Thyrotropin-releasing hormone

Stimulates secretionof thyroid- stimulating hormone and prolactin

Corticotropin-releasing hormone

Causes release of adrenocorticotropic hormone

Growth-hormone releasing hormone

Causes release of growth hormone

Growth hormone inhibitory hormone (somatostatin)

Inhibits release of growth hormone

Gonadotropin-releasing hormone

Causes release of luteinizing hormone and follicle stimulating hormone

Dopamine or prolactin-inhibiting hormone

Inhibits release of prolactin

1. Thyrotropin-releasing hormone


2. Corticotropin-releasing hormone


3. Growth hormone-releasing hormone


4. Growth hormone inhibitory hormone (somatostatin)


5. Gonadotropin-releasing hormone


6. Dopamine or prolactin-inhibiting factor

Hormones of the Hypothalamus

Growth hormone

Stimulates protein synthesis and overall growth of most cells and tissues

Thyroid-stimulating hormone

Stimulates synthesis and secretion of thyroid hormones (thyroxine and triiodothyronine)

Adrenocorticotropic hormone

Stimulates synthesis and secretion of adrenocortical hormones (cortisol, androgens, and aldosterone)

Prolactin

Promotes development of the female breasts and secretion of milk

Follicle-stimulating hormone

Causes growth of follicles in the ovaries and sperm maturation in Sertoli cells of testes

Luteinizing hormone

Stimulates testosterone synthesis in Leydig cells of testes; stimulates ovulation, formation of corpus luteum, and estrogen and progesterone synthesis in ovaries

Growth hormone


Thyroid-stimulating hormone


Adrenocorticotropic hormone


Prolactin


Follicle-stimulating hormone


Luteinizing hormone

Hormones of the Anterior Pituitary

Antidiuretic hormone (aka vasopressin)

Increases water reabsorption by the kidneys and causes vasoconstriction and increased blood pressure

Oxytocin

Stimulates milk ejection from breasts and uterine contractions

Oxytocin


Antidiuretic hormone (vasopressin)

Hormones of the posterior pituitary

Thyroxine (t4) and triiodothyronine (t3)

Increases the rates of chemical reactions in most cells, thus increasing body metabolic rate

Calcitonin

Promotes deposition of calcium in the bones and decreases extracellular fluid calcium ion concentration

Thyroxine and triiodothyronine


Calcitonin

Hormones of the thyroid

Cortisol

Has multiple metabolic functions for controlling metabolism of proteins, carbohydrates, and fats; also has anti inflammatory effects

Aldosterone

Increases renal sodium reabsorption, potassium secretion, amd hydrogen ion secretion

Cortisol


Aldosterone

Hormones of the andrenal cortex

Norepinephrine and epinephrine

Adrenal medulla; Same effect as sympathetic stimulation

Insulin

Promotes glucose entry in many cells, and in this way controls carbohydrate metabolism

Glucagon

Increases synthesis abd release of glucose from the liver into the body fluids

Insulin


Glucagon

Hormones of the pancreas

Parathyroid hormone

Controls serum calcium ion concentration by increasing calcium absorption by the gut and kidneys and releasing calcium from bones

Testosterone

Promotes development of malereproductive system and make secondary sexual characteristics

Estrogens

Promotes growth and development of female reproductive system, female breasts, and female secondary sexual characteristics

Progesterone

Stimulates secretion of uterine milk by the uterine endometrial glands and promotes development our secretory apparatus of breasts

Human chorionic gonadotropin

Promotes growth of the corpus luteum and secretion of estrogens and progesterone by corpus luteum

Human somatomammotropin

Probably helps promote development of some fetal tissues, as well as mother's breasts

Human chorionic gonadotropin


Human somatomammotropin


Estrogen


Progesterone

Hormones of the Placenta

Renin

Catalyzes conversion of angiotensinogen to angiotensin I (acts as enzyme)

1,25-dihydroxycholecalciferol

Increases intestinal absorption of calcium and bone mineralization

Erythropoietin

Increases erythrocyte production

Atrial natriuretic peptide

Increases sodium secretion by kidneys, reduces blood pressure

Gastrin

Stimulates hydrogen chloride secretion by parietal cells

Secretin

Stimulates pancreatic acinar cells to release bicarbonate and water

Cholecystokinin

Stimulates gallbladder contraction and release of pancreatic enzymes

Leptin

Adipocytes;


Inhibits appetite, stimulates thermogenesis

Renin


1,25 dihydroxycholecalciferol


Erthropoietin

Hormones of the kidney

Secretin


Cholecystokinin

Small intestine hormones

Renin-angiotensin-aldosterone system (RAAS)

Plays an important role in regulating blood volume and systemic vascular resistance, which together influence cardiac output and arterial pressure

Renin


Angiotensin


Aldosterone

Components of RAAS

Renin

Released primarily by kidneys, stimulates the formation of angiotensin in blood and tissues, which in turn stimulates release of aldosterone from adrenal cortex

Angiotensinogen

Under goes proteolytic cleavage to form the decapeptide angiotensin I

Angiotensin converting enzyme (ACE)

that cleaves off two amino acids to form octapeptidez angiotensin II

Diabetes mellitus

Is a group of metabolic diseases characterized by inappropriate hyperglycemia resulting from defects in insulin secretion, insulin action, or both

Acute hyperglycemia

Polyuria, polydipsia, polyphagia, weight loss, blurred vision, fatigue, headache, and poor wound healing

Chronic hyperglycemia

Organ failure including the eyes, heart, kidney, blood vessels and nerves

T1DM

absolute insulin deficiency

T2DM

Most common form, insulin resistance

Gestational DM

women first exhibit elevated levels of plasma glucose during pregnancy

Genetic defects with B cell functions

MODY defects

Genetic defects in insulin function

Extreme insulin resistance syndrome

Endocrinopathies

Pheochromocytoma, Cushing's syndrome

Drug

Chemical induced DM

Uncommon forms of immune mediated DM

stiff person syndrome

Prediabetes

High sugar level but never enough for diabetes

126 mg/dL

Fasting blood glucose

200 mg/dL

Random (casual) blood glucose and symptoms of hyperglycemia

200 mg/dL

Oral glucose tolerance test

Greater than equal => 6.5%

A1c

92 ml/dL


1 hr 180 mg/dl


2 hr 153 mg/dl

Diagnosis of gdm based on OGTT

100 to 125 mg/dl

Impaired fasting glucose

140 to 199mg/dl

Impaired glucose tolerance

Rapid acting insulin

Lispro (Humalog), aspart (NovoLog), and glulisine (Apidra) insulins

Short acting insulin

Regular insulin (humulin regular, novolim regular)

Intermediate acting insulin

Isophane insulin suspension (neutral protamine hagedorn; NPH) insulin

Long acting insulins

Glargine (lantus) and detemir (levemir) insulins

Pre-mixed insulin

50/50 70/30 75/25

Extemporaneous mixtures

Two insulins mixed in one syringe, before administration

Insulin secretagogues

Sulfonylureases, meglitinides, phenylalanine derivatives

Biguanides

Metformin

Thiazolidinediones

Pioglitazone (Actos), Rosiglitazone (Avandia)

a Glucosidase Inhibitors

Acarbose, Miglitol

Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors

Sitagliptin (Januvia) Saxaglliptin (Onglyza), Linagliptin (Tradjenta)

Dopamine Agonist

Bromocriptine (cycloset)

Bile acid sequestrant

Colesevelam (welchol)

Glucovance

Metformin/glyburide

Metaglip

Metformin/glipizide

Avandame: RAM

Metformin/rosiglitazone

Actoplus Met, Actoplus Met XR

Metformin/pioglitazone

PrandiMet

Metformin/repaglinide

Kombiglyze

Metformin/saxagliptin

Janumet, Janumet XR

Metformin/sitagliptin

Avandaryl

Rosiglitazone/glimepiride

Duetact

Pioglitazone/glimepiride

Incretin Mirnetics (GLP 1 agonists)

Exenatide (byetta), Liraglutide (Victoza)

Hypoglycemia

Is the limiting factor for providing aggressive insulin therapy in individuals with T1DM and T2DM

Matter

Anything that occupies space and has mass

Energy

Property of matter and radiation that is a manifest of a capacity to do work

Intrinsic/Intensive Properties

Mass/amount independent properties


Ex. MP, BP, density, optical activity, etc

Extrinsic/Extensive Properties

Mass/amount dependent properties


Ex. mass, volume, heat content, etc

Element

Simplest only one kind of an atoem

Compound

Composed of 2 or more elements that are not chemically combined in definite proportions

Mixture

Composed off two or more substances that are not chemically combined and can be separated by physical means

Homogenous

One phase mixture

Heterogeneous

Mixtures consisting of two or more distinct phases (suspensions, coarse mixtures)

Physical change

Change in phase only, no chemical reaction occurs

Chemical change

Chemical reaction occurs there is a change in the intrinsic and extrinsic properties

Democritus

Matter is made up of small indivisible particles; atomos means indivisible

John dalton

Billiard ball model

Jj thomson

Raisin bread model; the negatively charged particles are evenly distributed throughout a solid positively charged particles

Ernest Rutherford

Preformed the gold film experiment; confirmed that the atom is nearly an empty space

Neil bohr

Planetary model; negatively charged particles (electrons) revolve around a positively charged nucleus

James Chadwick

Discovered the neutron

Erwin schrodinger

Quantum mechanical order

Isotopes

Same number od protons but with different number of neutrons

Isobars

Isotopes of different elements with the same atomic weight

Isotones

Different elements with the same number of neutrons

Orbital

Region in space where the probability of finding an electron is greatest; each electron may be defined by a set of values called quantum numbers

Principal

Main energy level, determines the size of the atom

Azimuthal

Subshell/sublevel, determines the shape of the orbital

Magnetic

Determines the orientation of the electron

Spin

The spin of the electron

Pauli's exclusion principle

No two electrons have the same set of quantum numbers

Heisenberg Uncertainty Principle

It is impossible to determine simultaneously the momentum and the position of an electron

Aufbau's building up principle

Lower energy levels are filled up first

Hund's rule of maximum multiplicity

Orbitals have to fill up singly first before pairing up

Antoine Lavoisier

Father of modern chemistry

Johann Dobereiner

Arranged elements into triads

Newland

Arranged elements into octaves

Meyer/Mendeleev

Modern periodic table

Periods

Rows

Group

Columns

Atomic radius

1/2 the distance between the nuclei, increase right to left; top to bottom

Electronegativity

Ability to attract electron clouds in a covalent bond. Increase left to right; bottom to top

Ionization energy

Energy required to remove an electron; inreased left to right, bottom to top

Electron affinity

Ability to accept an electron, to become a negatively charged ion


Increase left to right; bottom to top

Chemical bonds

Intramolecular forces that holds the molecule together

Ionic bond

Transfer of electron/s from an atom to another atomelb(M becomes cations; NM become anions)

Covalent bond

Sharing of electron pairs between atoms; the bond may be polar ir a nonpolar bond (depending on the electronegativities of atoms)

Polar bond

Difference of 1.7 - 0.5

Non polar bond

Difference of < or equal to 0.4

Chemical reaction

Process in which substances is changed into one or more new substances

Combination reaction

X + y = xy

Decomposition reaction

Xy = x + y

Single replacement (displacement)

X + yz = y + xz

Double replacement (or exchange)

Ax + by --> ay + bx

Neutralization

Acid and base reacts to form salt and water

Combustion reaction

Reaction of a substance with oxygen that proceeds with the evolution of heat and light

REDOX reaction

Transfer of electrons from one reactant to another reactant

Helium

2nd lightest gas; brown container

Donald duck like sound

Helium toxicity

Neon

Aka new; used in advertising

Argon

Lazy

Argon

Most abundant and widely distributed of all noble gases

Krypton

Aka hidden

Krypton

Least abundant of all noble gases; has inhalational anaesthetic activity

Xenon

Aka strangerh with inhalational anaesthetic activity

Radon

Aka Niton

Radon

Synthetic noble gas; recovered from radon and used in chemotherapy

Hydrogen

Aka inflammable air

Hydrogen

Lightest element

Protium

Most abundant isotope of hydrogen

Deuterium

Heavy hydrogen of isotopes of hydrogen

Tritium

The radioactive isotope

Lithium

Aka Earth

Lithium

Lightest metal; depressant, diuretic

Lithium bromide

Used as a depressant

Lithium carbonate (lithase)

Drug of choice for mania

Sodium

Aka Natrium

Sodium

Most abundant extracellular cation; cation of choice to optimize the pharmaceutical utility of organic medicaments

Sodium bicarbonate

Aka baking soda, used as a systemic antacid or carbonating agent

Sodium dihydrogen phosphate

Aka Fleet enema, used as a cathartic and source of PO4 3-

Sodium bisulfite

Aka Leucogen; an antioxidant

Sodium carbonate

Aka soda ash, used as an antacid and a carbonating agent

Soda ash

Sodium carbonate anhydrous

Trona

Sodium carbonate dihydrate

Washing soda, sal soda, and soda crystals

Sodium carbonate decahydrate

Sodium fluoride

Anticariogenic (2%)

Sodium hydroxide

Aka Caustic Soda

Sodium hydroxide or Caustic Soda

Saponifying agent in the production of hard/bar soap

Sodium hypochlorite

Aka Dakin's solution, Modified Dakin's solution (diluted), used as a germicide

Sodium nitrite

Treatment if cyanide poisoning; used as a meat preservative, antioxidant

Sodium nitrate

Aka Chile Salt Peter

Sodium nitrate or Chile Salt Peter

Used as a meat preservative or vasodilator

Sodium sulfate

Aka Glauber's salt, used as a cathartic

Sodium tartrate

Primary standard for Karl Fischer reagent for water content determination

Sodium thiocyanate

Hypertensive agent

Sodium thiosulfate

Aka hypochlor or photographer's hypo

Sodium thiosulfate

Treatment CN poisoning along Na nitrite

Potassium

Aka Kalium

Potassium

Most abundant intracellular cation; pharmacologic action: diuretic, important in muscular contraction


Sources: avocado, banana

Potassium bitartrate

Aka cream of tartar or creamor; used as a laxative

Potassium carbonate

Aka potash, perlash, salt of peter

Potassium chlorate

An oxidizing agent, component of toothpastes, gargles, and mouthwash

Potassium chloride

Aka Kalium chloratum, used as an electrolyte replenisher

Potassium hydroxide

Aka caustic potash and lye potash

Potassium hydroxide

Used as a saponifying agent in the preparation pf soft or liquid soap

Potassium iodide

Aka kalium jodatu

Potassium nitrate

Aka salt peter, salt prunelle or salitre

Potassium permanganate

Aka mineral chameleon

Potassium permanganate

Used as an oxidizing agent, antiseptic (0.02%) and treatment for strychnine poisoning

Potassium sodium tartrate

Aka rochelle salt, sal signette; used as a cathartic

Potassium thiocyanate

Hypertensive agent

Sulfurated potash

Aka liver of sulfur, heparis sulfuris, a mixture of potassium sulfide, potassium polysulfide and potassium thiosulfate; used in the preparation of white lotion

Ammonium

Hypothetical alkali metal

Ammonium carbonate

Salt volatile, hartshorn, preston salt, baker's ammonia


Expectorant and respiratory stimulant

Ammonium chloride

Aka muriate of hartshorn

Aromatic ammonia spirit

Aka spirit of sal volatile, spirit of hartshorn; a mixture of ammonium carbonate and strong ammonia solution; used as a respiratory stimulant

Ammoniated mercury

Aka white precipitate, used as a topical anti infective

Ammonium acetate

Aka spirit of minderesus, used as styptic

Copper

Aka Cuprum, only reddish metal

Brass

Cu and Zinc

Bronze

Cu and Sn

Wilson's disease

Toxicity of Copper

Penicillamine

Antidote for copper toxicity or Wilson's disease

Copper sulfate

Blue vitriol/blue stone

Copper sulfate

Antidote for phosphorus poisoning; ingredient of Bordeaux mixture

Copper acetoarsenate

Aka paris green, used as an insecticide

Silver

Aka argentum, shining bright, has oligodynamic action

Argyria

Silver toxicity

NSS

Antidote for argyria

Silver nitrate

Aka lunar caustic, inedible ink and caustic pencil; used for the treatment of warts, eye antiseptic of babies and wet dressing for 3rd degree burns

Ammoniacal silver nitrate

Used as a dental protective

Gold

Aka aurum, shining dawn, king of all metals

Gold dermatitis

Gold toxicity

Dimercaprol

Antidote for gold toxicity

Aurothioglucose and Gild Na thiomalate

Given IM for the treatment of gout and rheumatoid arthritis

Auranofin

Given orally for guot and RA

Beryllium

Most toxic metal

Magnesium

Found in chlorophyll

Magnesium

2nd most abundant intracellular cation: lightest of all structural metal; is a natural calcium channel blocker

Ca gluconate

Antidote for magnesium toxicity

Magnesium carbonate

Aka magnesia

Magnesium hydroxide

Aka milk of magnesia or magnesia magma

Magnesium oxide

Aka calcined magnesia; a component of the universal antidote

Magnesium sulfate

Epsom salt; cathartic, anticonvulsant, antidote for baritosis

Hydrated magnesium silicate

Aka talc, soapstone or french chalk; softest mineral known; used as a dusting powder, filtering aid and adsorbent

Calcium

2nd most abundant cation in the ECF, vitamin d is needed for its adsorption

Calcium carbonate

Precipitated chalk or prepared chalk

Calcium chloride

Aka muriate of lime

Calcium gluconate

Ca supplement and replenisher

Calcium hypochlorite

Aka chlorinated lume

Calcium phosphate

Aka bone ash

Calcium hydroxide

Aka slaked lime, hydrated lime or milk of lime

Calcium oxide

Aka quicklime, lime or calx, ingredient of Bordeaux mixture and as insecticide

Calcium sulfate

aka plaster of paris (as hemihydrate) or gypsum (as dihydrate), used as a rodenticide, in the preparation of surgical casts

Strontium

Used in the manufacture of flares

Strontium chloride

Used as a desensitizing agent ( in sensodyne)

Barium

Aka heavy

Baritosis

Barium toxicity

Barium sulfate

A radiopawue for GIT imaging (as a contrast media)

Zinc

Metal present in insulin and component of carbonic anhydrase

Parakeratosis

Zinc deficiency

Metal fume fever

Zinc toxicity

Zinc chloride

Aka burnett's disinfectant fluid, used as dentin desensitizer

Zinc oxide

Zinc white or Lassar's paste

Zinc sulfate

White vitriol, used in preparation of white lotion

Zinc sulfide

Whute sulfide, active ingredient in white lotion

Cadmium

Used in the manufacture of stink bombs

Itai itai disease

Cadmium poisoning

BAL/Dimercaprol

Antidote for itai itai disease

Cadmium sulfate

A topical astringent and cure for eye infections

Cadmium sulfide

Aka greenockite or yellow sulfide; treatment of seborrheic dermatitis

Mercury

Aka Hydrargyrum, quicksilver, messenger of gods, true metal that is liquid at room temperature

Egg albumin

Antidote for emergency poisoning of mercury

Bichloride of Na formaldehyde sulfoxylate

True antidote for mercury toxicity

Edta

Minamata disease antidote

Minamata disease

Poisoning of mercury

Mercurous chloride

Aka calomel : cathartic and local antiseptic

Mercuric chloride

Aka corrosive sublimate; disinfectant

Mercuric oxide

Aka yellow precipitate, used as an optjalmic antiseptic

Boron

A metalloid, toxic by ingestion and used externally as a topical anti infective or eyewash

Boric acid

Sal sativum or sal sedativum


Buffer solution for ophthalmic solutions (2%)


Tonicity adjusting agent and as an eyewash at 2.5%

Lobster appearance

Boric acid toxicity

Borax

Na tetraborate or Dobell's solution - used as an antiseptic and eyewash

Aluminum

Most abundant metal; 3rd most abundant element



Gastric acid


Astringent


Foils for burn patient

Alum

Aka Tawas; astringent and perspirant or deodorant

Aluminum hydroxide

Aka Amphojel or Cremalin gel; used as an atancid and protectant

Aluminum phosphate

Aka phosphagel

Aluminum oxide

Aka alumina; used for the treatment of silicosis

Kaolin


Bentonite


Pumice

Aluminum silicates

Kaolin

Aka china clay or NHAS; absorbent or diarrhea

Bentonite

Aka soap clay, mineral soap or NCHAS, suspending agent

Pumice

Of volcanic