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289 Cards in this Set
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Endocrinology |
Study of the endocrine system. It covers the activities and structures of the system in health and disease |
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Homeostasis |
Internal conditions are maintained |
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Tissuea that detect internal change Tissues that synthesize hormones Hormones Target tissues that responds to hormonal sign |
Components of the endocrine system |
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Glands Heart Fat tissue Liver |
Tissues that synthesize hormones |
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Pituitary Thyroid Parathyroid Adrenal Pancreatic Gonads |
Classic endocrine glands |
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Negative feedback |
Stimulus that perturbs balance is corrected by initiating a physiologic response that opposes the stimulus |
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Positive feedback |
Event/stimulus is amplified by the endocrine system to facilitate and complete a task |
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Peptide hormones |
Are made up of amino acids. They are encoded by genes in the cells that synthesize them. These genes are responsive to long term and short term regulation |
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Steroidal hormones |
Are derived from further processing of membranes cholesterol. Concentration pressure and enzyme activity regulate the levels of these hormones |
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Thyrotropin-releasing hormone |
Stimulates secretionof thyroid- stimulating hormone and prolactin |
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Corticotropin-releasing hormone |
Causes release of adrenocorticotropic hormone |
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Growth-hormone releasing hormone |
Causes release of growth hormone |
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Growth hormone inhibitory hormone (somatostatin) |
Inhibits release of growth hormone |
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Gonadotropin-releasing hormone |
Causes release of luteinizing hormone and follicle stimulating hormone |
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Dopamine or prolactin-inhibiting hormone |
Inhibits release of prolactin |
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1. Thyrotropin-releasing hormone 2. Corticotropin-releasing hormone 3. Growth hormone-releasing hormone 4. Growth hormone inhibitory hormone (somatostatin) 5. Gonadotropin-releasing hormone 6. Dopamine or prolactin-inhibiting factor |
Hormones of the Hypothalamus |
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Growth hormone |
Stimulates protein synthesis and overall growth of most cells and tissues |
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Thyroid-stimulating hormone |
Stimulates synthesis and secretion of thyroid hormones (thyroxine and triiodothyronine) |
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Adrenocorticotropic hormone |
Stimulates synthesis and secretion of adrenocortical hormones (cortisol, androgens, and aldosterone) |
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Prolactin |
Promotes development of the female breasts and secretion of milk |
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Follicle-stimulating hormone |
Causes growth of follicles in the ovaries and sperm maturation in Sertoli cells of testes |
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Luteinizing hormone |
Stimulates testosterone synthesis in Leydig cells of testes; stimulates ovulation, formation of corpus luteum, and estrogen and progesterone synthesis in ovaries |
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Growth hormone Thyroid-stimulating hormone Adrenocorticotropic hormone Prolactin Follicle-stimulating hormone Luteinizing hormone |
Hormones of the Anterior Pituitary |
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Antidiuretic hormone (aka vasopressin) |
Increases water reabsorption by the kidneys and causes vasoconstriction and increased blood pressure |
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Oxytocin |
Stimulates milk ejection from breasts and uterine contractions |
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Oxytocin Antidiuretic hormone (vasopressin) |
Hormones of the posterior pituitary |
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Thyroxine (t4) and triiodothyronine (t3) |
Increases the rates of chemical reactions in most cells, thus increasing body metabolic rate |
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Calcitonin |
Promotes deposition of calcium in the bones and decreases extracellular fluid calcium ion concentration |
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Thyroxine and triiodothyronine Calcitonin |
Hormones of the thyroid |
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Cortisol |
Has multiple metabolic functions for controlling metabolism of proteins, carbohydrates, and fats; also has anti inflammatory effects |
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Aldosterone |
Increases renal sodium reabsorption, potassium secretion, amd hydrogen ion secretion |
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Cortisol Aldosterone |
Hormones of the andrenal cortex |
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Norepinephrine and epinephrine |
Adrenal medulla; Same effect as sympathetic stimulation |
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Insulin |
Promotes glucose entry in many cells, and in this way controls carbohydrate metabolism |
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Glucagon |
Increases synthesis abd release of glucose from the liver into the body fluids |
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Insulin Glucagon |
Hormones of the pancreas |
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Parathyroid hormone |
Controls serum calcium ion concentration by increasing calcium absorption by the gut and kidneys and releasing calcium from bones |
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Testosterone |
Promotes development of malereproductive system and make secondary sexual characteristics |
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Estrogens |
Promotes growth and development of female reproductive system, female breasts, and female secondary sexual characteristics |
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Progesterone |
Stimulates secretion of uterine milk by the uterine endometrial glands and promotes development our secretory apparatus of breasts |
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Human chorionic gonadotropin |
Promotes growth of the corpus luteum and secretion of estrogens and progesterone by corpus luteum |
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Human somatomammotropin |
Probably helps promote development of some fetal tissues, as well as mother's breasts |
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Human chorionic gonadotropin Human somatomammotropin Estrogen Progesterone |
Hormones of the Placenta |
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Renin |
Catalyzes conversion of angiotensinogen to angiotensin I (acts as enzyme) |
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1,25-dihydroxycholecalciferol |
Increases intestinal absorption of calcium and bone mineralization |
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Erythropoietin |
Increases erythrocyte production |
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Atrial natriuretic peptide |
Increases sodium secretion by kidneys, reduces blood pressure |
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Gastrin |
Stimulates hydrogen chloride secretion by parietal cells |
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Secretin |
Stimulates pancreatic acinar cells to release bicarbonate and water |
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Cholecystokinin |
Stimulates gallbladder contraction and release of pancreatic enzymes |
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Leptin |
Adipocytes; Inhibits appetite, stimulates thermogenesis |
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Renin 1,25 dihydroxycholecalciferol Erthropoietin |
Hormones of the kidney |
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Secretin Cholecystokinin |
Small intestine hormones |
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Renin-angiotensin-aldosterone system (RAAS) |
Plays an important role in regulating blood volume and systemic vascular resistance, which together influence cardiac output and arterial pressure |
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Renin Angiotensin Aldosterone |
Components of RAAS |
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Renin |
Released primarily by kidneys, stimulates the formation of angiotensin in blood and tissues, which in turn stimulates release of aldosterone from adrenal cortex |
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Angiotensinogen |
Under goes proteolytic cleavage to form the decapeptide angiotensin I |
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Angiotensin converting enzyme (ACE) |
that cleaves off two amino acids to form octapeptidez angiotensin II |
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Diabetes mellitus |
Is a group of metabolic diseases characterized by inappropriate hyperglycemia resulting from defects in insulin secretion, insulin action, or both |
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Acute hyperglycemia |
Polyuria, polydipsia, polyphagia, weight loss, blurred vision, fatigue, headache, and poor wound healing |
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Chronic hyperglycemia |
Organ failure including the eyes, heart, kidney, blood vessels and nerves |
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T1DM |
absolute insulin deficiency |
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T2DM |
Most common form, insulin resistance |
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Gestational DM |
women first exhibit elevated levels of plasma glucose during pregnancy |
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Genetic defects with B cell functions |
MODY defects |
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Genetic defects in insulin function |
Extreme insulin resistance syndrome |
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Endocrinopathies |
Pheochromocytoma, Cushing's syndrome |
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Drug |
Chemical induced DM |
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Uncommon forms of immune mediated DM |
stiff person syndrome |
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Prediabetes |
High sugar level but never enough for diabetes |
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126 mg/dL |
Fasting blood glucose |
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200 mg/dL |
Random (casual) blood glucose and symptoms of hyperglycemia |
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200 mg/dL |
Oral glucose tolerance test |
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Greater than equal => 6.5% |
A1c |
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92 ml/dL 1 hr 180 mg/dl 2 hr 153 mg/dl |
Diagnosis of gdm based on OGTT |
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100 to 125 mg/dl |
Impaired fasting glucose |
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140 to 199mg/dl |
Impaired glucose tolerance |
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Rapid acting insulin |
Lispro (Humalog), aspart (NovoLog), and glulisine (Apidra) insulins |
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Short acting insulin |
Regular insulin (humulin regular, novolim regular) |
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Intermediate acting insulin |
Isophane insulin suspension (neutral protamine hagedorn; NPH) insulin |
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Long acting insulins |
Glargine (lantus) and detemir (levemir) insulins |
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Pre-mixed insulin |
50/50 70/30 75/25 |
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Extemporaneous mixtures |
Two insulins mixed in one syringe, before administration |
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Insulin secretagogues |
Sulfonylureases, meglitinides, phenylalanine derivatives |
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Biguanides |
Metformin |
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Thiazolidinediones |
Pioglitazone (Actos), Rosiglitazone (Avandia) |
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a Glucosidase Inhibitors |
Acarbose, Miglitol |
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Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors |
Sitagliptin (Januvia) Saxaglliptin (Onglyza), Linagliptin (Tradjenta) |
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Dopamine Agonist |
Bromocriptine (cycloset) |
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Bile acid sequestrant |
Colesevelam (welchol) |
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Glucovance |
Metformin/glyburide |
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Metaglip |
Metformin/glipizide |
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Avandame: RAM |
Metformin/rosiglitazone |
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Actoplus Met, Actoplus Met XR |
Metformin/pioglitazone |
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PrandiMet |
Metformin/repaglinide |
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Kombiglyze |
Metformin/saxagliptin |
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Janumet, Janumet XR |
Metformin/sitagliptin |
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Avandaryl |
Rosiglitazone/glimepiride |
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Duetact |
Pioglitazone/glimepiride |
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Incretin Mirnetics (GLP 1 agonists) |
Exenatide (byetta), Liraglutide (Victoza) |
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Hypoglycemia |
Is the limiting factor for providing aggressive insulin therapy in individuals with T1DM and T2DM |
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Matter |
Anything that occupies space and has mass |
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Energy |
Property of matter and radiation that is a manifest of a capacity to do work |
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Intrinsic/Intensive Properties |
Mass/amount independent properties Ex. MP, BP, density, optical activity, etc |
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Extrinsic/Extensive Properties |
Mass/amount dependent properties Ex. mass, volume, heat content, etc |
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Element |
Simplest only one kind of an atoem |
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Compound |
Composed of 2 or more elements that are not chemically combined in definite proportions |
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Mixture |
Composed off two or more substances that are not chemically combined and can be separated by physical means |
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Homogenous |
One phase mixture |
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Heterogeneous |
Mixtures consisting of two or more distinct phases (suspensions, coarse mixtures) |
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Physical change |
Change in phase only, no chemical reaction occurs |
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Chemical change |
Chemical reaction occurs there is a change in the intrinsic and extrinsic properties |
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Democritus |
Matter is made up of small indivisible particles; atomos means indivisible |
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John dalton |
Billiard ball model |
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Jj thomson |
Raisin bread model; the negatively charged particles are evenly distributed throughout a solid positively charged particles |
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Ernest Rutherford |
Preformed the gold film experiment; confirmed that the atom is nearly an empty space |
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Neil bohr |
Planetary model; negatively charged particles (electrons) revolve around a positively charged nucleus |
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James Chadwick |
Discovered the neutron |
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Erwin schrodinger |
Quantum mechanical order |
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Isotopes |
Same number od protons but with different number of neutrons |
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Isobars |
Isotopes of different elements with the same atomic weight |
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Isotones |
Different elements with the same number of neutrons |
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Orbital |
Region in space where the probability of finding an electron is greatest; each electron may be defined by a set of values called quantum numbers |
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Principal |
Main energy level, determines the size of the atom |
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Azimuthal |
Subshell/sublevel, determines the shape of the orbital |
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Magnetic |
Determines the orientation of the electron |
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Spin |
The spin of the electron |
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Pauli's exclusion principle |
No two electrons have the same set of quantum numbers |
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Heisenberg Uncertainty Principle |
It is impossible to determine simultaneously the momentum and the position of an electron |
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Aufbau's building up principle |
Lower energy levels are filled up first |
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Hund's rule of maximum multiplicity |
Orbitals have to fill up singly first before pairing up |
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Antoine Lavoisier |
Father of modern chemistry |
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Johann Dobereiner |
Arranged elements into triads |
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Newland |
Arranged elements into octaves |
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Meyer/Mendeleev |
Modern periodic table |
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Periods |
Rows |
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Group |
Columns |
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Atomic radius |
1/2 the distance between the nuclei, increase right to left; top to bottom |
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Electronegativity |
Ability to attract electron clouds in a covalent bond. Increase left to right; bottom to top |
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Ionization energy |
Energy required to remove an electron; inreased left to right, bottom to top |
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Electron affinity |
Ability to accept an electron, to become a negatively charged ion Increase left to right; bottom to top |
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Chemical bonds |
Intramolecular forces that holds the molecule together |
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Ionic bond |
Transfer of electron/s from an atom to another atomelb(M becomes cations; NM become anions) |
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Covalent bond |
Sharing of electron pairs between atoms; the bond may be polar ir a nonpolar bond (depending on the electronegativities of atoms) |
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Polar bond |
Difference of 1.7 - 0.5 |
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Non polar bond |
Difference of < or equal to 0.4 |
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Chemical reaction |
Process in which substances is changed into one or more new substances |
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Combination reaction |
X + y = xy |
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Decomposition reaction |
Xy = x + y |
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Single replacement (displacement) |
X + yz = y + xz |
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Double replacement (or exchange) |
Ax + by --> ay + bx |
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Neutralization |
Acid and base reacts to form salt and water |
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Combustion reaction |
Reaction of a substance with oxygen that proceeds with the evolution of heat and light |
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REDOX reaction |
Transfer of electrons from one reactant to another reactant |
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Helium |
2nd lightest gas; brown container |
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Donald duck like sound |
Helium toxicity |
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Neon |
Aka new; used in advertising |
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Argon |
Lazy |
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Argon |
Most abundant and widely distributed of all noble gases |
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Krypton |
Aka hidden |
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Krypton |
Least abundant of all noble gases; has inhalational anaesthetic activity |
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Xenon |
Aka strangerh with inhalational anaesthetic activity |
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Radon |
Aka Niton |
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Radon |
Synthetic noble gas; recovered from radon and used in chemotherapy |
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Hydrogen |
Aka inflammable air |
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Hydrogen |
Lightest element |
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Protium |
Most abundant isotope of hydrogen |
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Deuterium |
Heavy hydrogen of isotopes of hydrogen |
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Tritium |
The radioactive isotope |
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Lithium |
Aka Earth |
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Lithium |
Lightest metal; depressant, diuretic |
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Lithium bromide |
Used as a depressant |
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Lithium carbonate (lithase) |
Drug of choice for mania |
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Sodium |
Aka Natrium |
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Sodium |
Most abundant extracellular cation; cation of choice to optimize the pharmaceutical utility of organic medicaments |
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Sodium bicarbonate |
Aka baking soda, used as a systemic antacid or carbonating agent |
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Sodium dihydrogen phosphate |
Aka Fleet enema, used as a cathartic and source of PO4 3- |
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Sodium bisulfite |
Aka Leucogen; an antioxidant |
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Sodium carbonate |
Aka soda ash, used as an antacid and a carbonating agent |
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Soda ash |
Sodium carbonate anhydrous |
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Trona |
Sodium carbonate dihydrate |
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Washing soda, sal soda, and soda crystals |
Sodium carbonate decahydrate |
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Sodium fluoride |
Anticariogenic (2%) |
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Sodium hydroxide |
Aka Caustic Soda |
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Sodium hydroxide or Caustic Soda |
Saponifying agent in the production of hard/bar soap |
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Sodium hypochlorite |
Aka Dakin's solution, Modified Dakin's solution (diluted), used as a germicide |
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Sodium nitrite |
Treatment if cyanide poisoning; used as a meat preservative, antioxidant |
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Sodium nitrate |
Aka Chile Salt Peter |
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Sodium nitrate or Chile Salt Peter |
Used as a meat preservative or vasodilator |
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Sodium sulfate |
Aka Glauber's salt, used as a cathartic |
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Sodium tartrate |
Primary standard for Karl Fischer reagent for water content determination |
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Sodium thiocyanate |
Hypertensive agent |
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Sodium thiosulfate |
Aka hypochlor or photographer's hypo |
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Sodium thiosulfate |
Treatment CN poisoning along Na nitrite |
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Potassium |
Aka Kalium |
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Potassium |
Most abundant intracellular cation; pharmacologic action: diuretic, important in muscular contraction Sources: avocado, banana |
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Potassium bitartrate |
Aka cream of tartar or creamor; used as a laxative |
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Potassium carbonate |
Aka potash, perlash, salt of peter |
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Potassium chlorate |
An oxidizing agent, component of toothpastes, gargles, and mouthwash |
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Potassium chloride |
Aka Kalium chloratum, used as an electrolyte replenisher |
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Potassium hydroxide |
Aka caustic potash and lye potash |
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Potassium hydroxide |
Used as a saponifying agent in the preparation pf soft or liquid soap |
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Potassium iodide |
Aka kalium jodatu |
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Potassium nitrate |
Aka salt peter, salt prunelle or salitre |
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Potassium permanganate |
Aka mineral chameleon |
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Potassium permanganate |
Used as an oxidizing agent, antiseptic (0.02%) and treatment for strychnine poisoning |
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Potassium sodium tartrate |
Aka rochelle salt, sal signette; used as a cathartic |
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Potassium thiocyanate |
Hypertensive agent |
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Sulfurated potash |
Aka liver of sulfur, heparis sulfuris, a mixture of potassium sulfide, potassium polysulfide and potassium thiosulfate; used in the preparation of white lotion |
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Ammonium |
Hypothetical alkali metal |
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Ammonium carbonate |
Salt volatile, hartshorn, preston salt, baker's ammonia Expectorant and respiratory stimulant |
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Ammonium chloride |
Aka muriate of hartshorn |
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Aromatic ammonia spirit |
Aka spirit of sal volatile, spirit of hartshorn; a mixture of ammonium carbonate and strong ammonia solution; used as a respiratory stimulant |
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Ammoniated mercury |
Aka white precipitate, used as a topical anti infective |
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Ammonium acetate |
Aka spirit of minderesus, used as styptic |
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Copper |
Aka Cuprum, only reddish metal |
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Brass |
Cu and Zinc |
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Bronze |
Cu and Sn |
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Wilson's disease |
Toxicity of Copper |
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Penicillamine |
Antidote for copper toxicity or Wilson's disease |
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Copper sulfate |
Blue vitriol/blue stone |
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Copper sulfate |
Antidote for phosphorus poisoning; ingredient of Bordeaux mixture |
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Copper acetoarsenate |
Aka paris green, used as an insecticide |
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Silver |
Aka argentum, shining bright, has oligodynamic action |
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Argyria |
Silver toxicity |
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NSS |
Antidote for argyria |
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Silver nitrate |
Aka lunar caustic, inedible ink and caustic pencil; used for the treatment of warts, eye antiseptic of babies and wet dressing for 3rd degree burns |
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Ammoniacal silver nitrate |
Used as a dental protective |
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Gold |
Aka aurum, shining dawn, king of all metals |
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Gold dermatitis |
Gold toxicity |
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Dimercaprol |
Antidote for gold toxicity |
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Aurothioglucose and Gild Na thiomalate |
Given IM for the treatment of gout and rheumatoid arthritis |
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Auranofin |
Given orally for guot and RA |
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Beryllium |
Most toxic metal |
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Magnesium |
Found in chlorophyll |
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Magnesium |
2nd most abundant intracellular cation: lightest of all structural metal; is a natural calcium channel blocker |
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Ca gluconate |
Antidote for magnesium toxicity |
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Magnesium carbonate |
Aka magnesia |
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Magnesium hydroxide |
Aka milk of magnesia or magnesia magma |
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Magnesium oxide |
Aka calcined magnesia; a component of the universal antidote |
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Magnesium sulfate |
Epsom salt; cathartic, anticonvulsant, antidote for baritosis |
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Hydrated magnesium silicate |
Aka talc, soapstone or french chalk; softest mineral known; used as a dusting powder, filtering aid and adsorbent |
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Calcium |
2nd most abundant cation in the ECF, vitamin d is needed for its adsorption |
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Calcium carbonate |
Precipitated chalk or prepared chalk |
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Calcium chloride |
Aka muriate of lime |
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Calcium gluconate |
Ca supplement and replenisher |
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Calcium hypochlorite |
Aka chlorinated lume |
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Calcium phosphate |
Aka bone ash |
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Calcium hydroxide |
Aka slaked lime, hydrated lime or milk of lime |
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Calcium oxide |
Aka quicklime, lime or calx, ingredient of Bordeaux mixture and as insecticide |
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Calcium sulfate |
aka plaster of paris (as hemihydrate) or gypsum (as dihydrate), used as a rodenticide, in the preparation of surgical casts |
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Strontium |
Used in the manufacture of flares |
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Strontium chloride |
Used as a desensitizing agent ( in sensodyne) |
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Barium |
Aka heavy |
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Baritosis |
Barium toxicity |
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Barium sulfate |
A radiopawue for GIT imaging (as a contrast media) |
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Zinc |
Metal present in insulin and component of carbonic anhydrase |
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Parakeratosis |
Zinc deficiency |
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Metal fume fever |
Zinc toxicity |
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Zinc chloride |
Aka burnett's disinfectant fluid, used as dentin desensitizer |
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Zinc oxide |
Zinc white or Lassar's paste |
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Zinc sulfate |
White vitriol, used in preparation of white lotion |
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Zinc sulfide |
Whute sulfide, active ingredient in white lotion |
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Cadmium |
Used in the manufacture of stink bombs |
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Itai itai disease |
Cadmium poisoning |
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BAL/Dimercaprol |
Antidote for itai itai disease |
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Cadmium sulfate |
A topical astringent and cure for eye infections |
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Cadmium sulfide |
Aka greenockite or yellow sulfide; treatment of seborrheic dermatitis |
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Mercury |
Aka Hydrargyrum, quicksilver, messenger of gods, true metal that is liquid at room temperature |
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Egg albumin |
Antidote for emergency poisoning of mercury |
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Bichloride of Na formaldehyde sulfoxylate |
True antidote for mercury toxicity |
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Edta |
Minamata disease antidote |
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Minamata disease |
Poisoning of mercury |
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Mercurous chloride |
Aka calomel : cathartic and local antiseptic |
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Mercuric chloride |
Aka corrosive sublimate; disinfectant |
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Mercuric oxide |
Aka yellow precipitate, used as an optjalmic antiseptic |
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Boron |
A metalloid, toxic by ingestion and used externally as a topical anti infective or eyewash |
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Boric acid |
Sal sativum or sal sedativum Buffer solution for ophthalmic solutions (2%) Tonicity adjusting agent and as an eyewash at 2.5% |
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Lobster appearance |
Boric acid toxicity |
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Borax |
Na tetraborate or Dobell's solution - used as an antiseptic and eyewash |
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Aluminum |
Most abundant metal; 3rd most abundant element Gastric acid Astringent Foils for burn patient |
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Alum |
Aka Tawas; astringent and perspirant or deodorant |
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Aluminum hydroxide |
Aka Amphojel or Cremalin gel; used as an atancid and protectant |
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Aluminum phosphate |
Aka phosphagel |
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Aluminum oxide |
Aka alumina; used for the treatment of silicosis |
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Kaolin Bentonite Pumice |
Aluminum silicates |
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Kaolin |
Aka china clay or NHAS; absorbent or diarrhea |
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Bentonite |
Aka soap clay, mineral soap or NCHAS, suspending agent |
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Pumice |
Of volcanic |