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16 Cards in this Set
- Front
- Back
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What is the cytokine which initiates clonal expansion |
IL-2 |
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What do activated CD4+ cells differentiate into |
Th1 cell which produces IL 2 and IFN gamma
Th2 Cell which produces IL 4 and IL 3 |
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What cytokine does Th1 cell produce |
IL2
IFN gamma |
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What cytokine does Th2 cell produce |
IL3 IL4 |
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What are the types of immunity controlled by Th1 and Th2 Cells |
Th1 - cell mediated immunity
Th2 - humoral immunity |
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How does cell mediated immunity work |
Th1 cells help macrophages:
Virus and bacteria live inside macrophages.
Th1 cells activate the macrophage to cause it to secrete an inner 'bleach' which kills all viruses and bacteria |
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How does the body deal with bacteria it cannot kill, e.g.. TB |
Immune system walls off the macrophages containing bacteria creating a caveating granuloma |
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How does humoral immunity work |
Th2 Cells initiate humoral immunity. They help B cells make antibodies |
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What is the concept of T cell help. |
T cell binds to dendritic cell containing antigen. Same T cell will bind to B cell presenting antigen on MHC class 2. Th2 Cell recognises that these are the same receptors and secretes cytokines, which prompt the B cell to release antibodies |
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B Cells can produce several antibody types, what are thy |
IgM, IgA, IgE, IgG |
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What is the structure of the antibodies |
IgM, Pentomer IgG monomer IgE monomer IgA dimer |
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What causes Th0 cells to differentiate into Th1 and Th2 cells |
Th1 - IL 12 or IL 23
Th2 - IL 4 |
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What are the 2 types of leprosy. Which type of Th cell affects each? |
Tuberculoid Leprocy Th1 dominant response IFN gamma is the activated cytokine
Lepromatous Leprocy: Th2 is dominant response IL-4 IL-5 IL-13 are activated cytokines |
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What are the 2 types of Leishmaniasis. Which type of Th cell affects each |
Cutaneous Leishmaniasis : Th1 is dominant response
Visceral Leishmaniasis Th2 Is dominant response |
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What are the 2 types of TB. Which type of Th cell affects each? |
Lepromatous TB: Th1 dominant
Miiliary TB Th2 dominant |
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How is type 1 hypersensitivity affected by Th1 and Th2 responses |
Th2 responds to allergy causing thing. Leads to production of IL 4. Leads to production of IgE, causes allergies |
