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17 Cards in this Set
- Front
- Back
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What are the qualifications for sepsis
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SIRS and documented infection
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What are the qualifications for SIRS? (3 of 4)
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1. Temperature > 38 or < 36
2. RR > 20 breaths/min or PCO2 < 32 mmHg or use of mechanical ventilation for an acute process 3. WBC > 12,000 or < 4000 or bands greater than 10% 4. HR > 90 bpm |
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What does SIRS stand for
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Systemic Inflammatory Response Syndrome
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What are the 4 things that can lead to a SIRS response (besides infection)
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1. Pancreatitis
2. Trauma 3. Burns 4. Hemorrhage |
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What is the only stage that medication can be used in
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Severe or 3rd stage of sepsis
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What is inhibited by sepsis
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The Anti-fibrinolytic Pathway....cant break down clots
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What is Activated Protein C
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1. anti-inflammatory
2. Anti-coagulant 3. Restores the antifibrinolytic Pathway |
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What is the indication for Drotrecogin Alfa Activated (Xigris)
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Reduction of mortality in adult patients with severe sepsis who have a high risk of death
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What are the adverse effects of Drotrecogin Alfa Activated (Xigris)
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bleeding
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What are the 4 primary criteria to receive Xigris
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1. Reasonable life expectancy
2. Full code status 3. Admission to an ICU 4. APACHE II score greater than 24 |
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What are the 2 other criteria for Xigris
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1. Known or suspected infection
2. No contraindications |
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What is the dosage for Xigris
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24 mcg/kg/hr for 96 hrs via dedicated central line
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What is the train of four stimulation
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4 stimuli are sent. How many twitches are seen determines the level of the blockade. lower the number the higher the blockade
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Non depolarizing neuromuscular blocking agent
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Completely block the neurotransmitter actylcholine (ACH) receptor at the post synaptic motor end plate.
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What NMBA (neuromuscular blocking agent) is recommended for normal renal/liver function
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vecuronium
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Recommended NMBA for liver failure
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cistracurium. doesnt require liver or renal function
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Recommended NMBA for Renal failure
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Cistracurium or low dose vecuronium
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