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13 Cards in this Set
- Front
- Back
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pK of human plasma
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6.1
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Standard bicarbonate concentration of plasma
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24 mM
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Standard partial pressure of CO2 in plasma (do NOT think about Ritucci)
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40 mm Hg
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The solubility coefficient of CO2 in plasma
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.03
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Henderson-Hasselbach of pH of human blood
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pH = pK' + log ([HCO3]/aPCO2)
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When pH is altered by the addition of a strong acid or base, what concentration changes?
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HCO3.
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Step 1
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Determine alkalosis or acidosis via blood pH.
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Step 2
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Determine respiratory or metabolic cause via change in PCO2. Rise in PCO2 means resp acid. Drop is resp alk.
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Step 3
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Acute or chronic resp disorder.
1. deltapH = .08 x (PCO2 - 40)/10 = acute acid 2. deltapH = .03 x (PCO2 - 40)/10 = chronic acid The signs will be reversed for alkalosis |
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Step 4
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Metabolic acidosis nature. Calc anion gap as Na - (Cl +HCO3)
Norm: Na 140, Cl 104, HCO3 24. Norm: anion gap 10-14 Rise in gap is met acid. Drop in gap is met alk. |
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What does a lack of anion gap change in Step 4 indicate for a met. alk/acid?
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The cause is not only using HC03 to buffer (or increase), it is also using Cl.
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Step 5
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Determine concommitant respiratory compensation (or not)
(1.5 x [HCO3]) + 8 +/- 2 = expected PCO2 High =Resp acid Low =Resp alk |
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Step 6
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Any additional metabolic disorders?
[HCO3] + anion gap - 12 Greater than 24 has met alk Less than 24 has met acid. |
