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18 Cards in this Set
- Front
- Back
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Catecholamine synthesis steps
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Tyrosine to L-DOPA (via TH)
L-DOPA to DA (via DOPA decarboxylase) DA to NE (via Dopamine-B-Hydroxylase) |
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How is Tyr Hydroxlase activated
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increase in enzyme affinity for BH4 cofactor
reduction of feedback inhibition Long term increase via CREB |
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Mechanisms of mapping CA pathways
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Formaldehyde exposure and flourescence imaging
immunohistochem with tagged antibody |
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AMPT
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inhibits TH
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Turning model
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Animals turn away from the stimulated side of the nigrostriatal pathway
After lesion Indirect- causes away from active side turning Direct- causes turning away from lesioned side (upregulation) |
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alpha-1receptor action
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vasoconstriction
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alpha-2 receptor action
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autoreceptor
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beta-1 receptor action
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stimulation of the heart
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beta-2 receptor action
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bronchodilation
glucose production (in response to epinephrine) |
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D1
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increase in cAMP
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D2 action
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decrease in cAMP
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Catecholamine antagonists
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Prazosin (a1)
Phentolalamine (a1/a2) Atenolol (B1 Propanolol (B1/B2) SCH 23390 (D1) Raclopride (D2) Haloperidol (D2/D3) |
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1,2,3 Altropane
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Positron emitter that binds to DA transporter -
helps visualize Parkinsons in vivo |
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Synuclein
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When mutated in parkinsons: aggregate proteins interfere with proteosome action
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Parkin
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When mutated in parkinsons:
part of the ubiquitin proteosome complex, reduces proteosome function |
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Ropinirole
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DA agonist used to treat parkinsons
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DA metabolites
NE metabolites |
HVA and DOPAC
MHPG and VMA |
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MPP+
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like 6-OHDA destroys DA neurons
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