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3 Cards in this Set
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- Back
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Alpha-methyltyrosine |
Tyrosine hydroxalse false substrate. ( inhibitor ) causes depletion of catecholamine. Used in pheochromocytoma |
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L-Dopa |
Precursor of dopamine. Used in Parkinson. Crosses BBB. Combined with carbidopa. Carbidopa doesn’t crosses BBB. Carbidopa is a dopa decarboxylase inhibitor. |
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Alpha-MethylDopa. |
2 effects. 1st is that it is a competitive inhibitor of dopa decarboxylase. So no formation of dopamine or NE or adrenaline.
2nd is that it is converted into Alpha-Methylnorepinephrine by dopamine beta hydroxylase. Alpha-Methylnorepinephrine is a alpha2 agonist. So inhibit sympathetic nervous system. Same as clonidine. |
