Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
In what peripheral organ are blood borne antigens stored
|
The spleen
|
|
|
In what peripheral organ are antigens from epithelium and connective tissue stored
|
Lymph nodes
|
|
|
T or F Dendritic cells are mature as soon as the bind an antigen
|
False
Dendritic cells undergo maturation during their migration to a naive T cell in a lymph node (when they meet the T cell they are mature) |
|
|
Are one or both parents alleles of each MHC gene expressed
|
BOTH
|
|
|
3 cell types that express MHC II
|
Dendritic cells, macrophages, B cells
|
|
|
In MHC Class I processing, how does the cytosolic antigen find the MHC complex in the ER in order to be bound and presented?
|
There is a transport molecule in the ER membrane that is called TAP (transporter assoc. with antigen processing)
this binds cytoplasm peptides and pumps them to the interior of the ER where they are bound by MHC I proteins |
|
|
What's the function of follicular dendritic cells?
|
To display antigens to activated B cells
|
|
|
How many CDR's (hypervariable regions) are contained by the variable regions of the heavy and light chains respectively?
|
3 and 3
***Greatest variability is in CDR3 |
|
|
Explain the fragment of an antibody that contains the antigen recognition portion
|
"Fab"
the fragment contains a whole light chain attached to the V and first C domains of a heavy chain |
|
|
The different immunoglobulins (IgG, IgA, IgD, etc) are named according to their
|
Heavy chains
|
|
|
Which Kd would cause the higher affinity: 10^-8 or 10^-11
|
10^-11, the lower the Kd the higher the affinity
|
|
|
What has a higher antigen binding affinity: Immunoglobulins or T cell receptors
|
Immunoglobulin
|
|
|
Survival and proliferation of the earliest lymphocyte precursors are stimulated mainly by the growth factor ____
|
IL-7
|
|
|
1st lymphocyte checkpoint: Failure to express pre-____receptor
|
Lymphocyte
|
|
|
2nd lymphocyte checkpoint: Failure to express ____ receptor
|
Antigen
|
|
|
Last 2 lymphocyte development checkpoints: Both regard what?
|
Self antigen recognition: Cell is killed if it exhibits STRONG self antigen recognition or exhibits NO self antigen recognition
The one that continues to mature is the cell that attributes weak self antigen recognition (positive selection) |
|
|
The process of eliminating potentially dangerous lymphocytes that may be capable of reacting against self antigens is known as_ ____ _ _ _ _ _ ___
|
Negative Selection
|
|
|
The somatic recombination of V and J genes or V, D , and J genes is mediated by a group of enzymes collectively called the __________
|
VDJ recombinase
|
|
|
Diversity of antigen receptors is produced by the use of different combinations of what 3 genes
|
V D and J
|
|
|
Do IgG's or TCR's have greater number of V gene segments?
|
IgG's have greater number of V gene segments
|
|
|
Which receptor (IgG or TCR) has the greater number of Diversity genes and Joining segments
|
IgG has greater # of D genes
TCR has greater # of J genes |
|
|
Which one IgG or TCR has the greater number of possible VDJ combinations
|
TCR
|
|
|
The hallmark of pre-B cells is cytoplasmic
|
"myu" m
|
|
|
What's the process that shuts off recombination of Ig heavy chain genes on the second chromosome called
|
Allelic exclusion
this helps ensure that each cell can expres receptors of a single specificity |
|
|
Failure of a developing Tcell to express the alpha chain and the complete TCR again results in
|
Death of the cell
|
