Case 4 Path Immuno

Front 1

Cellular immunity is mediated by

Back 1

T lymphocytes (humoral is B cells)

Front 2

On the T cell receptor what heterodimer recognizes the MHC

Back 2

alphaBeta TCR

Front 3

Analysis of antigen receptor gene rearrangements is a valuable assay for detecting

Back 3

Lymphoid tumors

Front 4

In T cells, analysis of Ig gene rearrangements is useful for identifying

Back 4

Monoclonal B-cell tumors

Front 5

Immature dendritic cells in the epidermis are called

Back 5

Langerhans Cells

Front 6

Dendritic cell found in lymphoid follicles in spleen an lymph nodes

Back 6

Follicular dendritic cell

Front 7

In peripheral lymphoid organs, B cells are concentrated in structures called ______. T lymphocytes are concentrated in the ______

Back 7

Follicles
Paracortex

Front 8

Naive T lymphocytes that exit the thymus migrate to lymph nodes through specialized postcapillary venules called

Back 8

high endotehlial venules (HEV's)

Front 9

The combination of HLA alleles (for MHC) in each individual is called the

Back 9

HLA haplotype

Front 10

Inflammatory diseases (ankylosing spondylitis, postinfectious arthropathies) are all associated with the HLA locus on which allele

Back 10

HLA-B27

Front 11

Autoimmune diseases (autoimmune endocrinopothies) are associated with HLA alleles at what locus

Back 11

The DR locus

Front 12

Inherited errors of metabolism, what HLA-alleles are associated with:
21 hydroxylase deficiency (1)
Hereditary Hemochromatosis (2)

Back 12

(1)HLA-BW47
(2)HLA-A

Front 13

Cytokines are made principally by

Back 13

CD4+ T lymphocytes

Front 14

Cytokines that stimulate hematopoieses are called

Back 14

Colony-stimulating factors

Front 15

Lymphocytes are made specific for an antigen before being exposed- when an antigen enters, it selects the specific cells and activates them ---this is an example of what fundamental concept

Back 15

Clonal selection hypothesis

Front 16

The principal costimulators for T cells are the __ proteins that are expressed on APCs and recognized by the CD28 receptor on naive T cells

Back 16

B7

Front 17

One of the earliest responses of CD4+ helper T cells is the secretion of the cytokine ___

Back 17

IL-2

Front 18

TH1 secretes what cytokine(s)

Back 18

IFN-y

Front 19

TH2 secretes what cytokine(s)

Back 19

IL-3, IL-4, IL-5

Front 20

T or F

You will destroy this exam

Back 20

T