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5 Cards in this Set
- Front
- Back
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* Reduced facial expression
* Pill rolling tremor * Quick shuffel gait * Rigidity, stooped posture * Lesion/dysfunction of nigrasriatal region |
Parkinsonism
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* Acute parkinsonism without toxicity or other etiology
* Lewy bodies * Palor of substantia nigra and ceruleus * Dopamine deficiency results in dementia |
Parkinson's Disease
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* Cerebellar atrophy
* cytoplasmic inclusions that include α synuclein, ubiquiton, and αB crystalline * Parkinsonism and orthostatic hypotension |
Multi System Atrophy
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* Progressive motor dysfunction ending in death within 10- 15 years
* Motor deficits preceed cognitive * forgetfullness, thought affected disorders, eventual severe dementia * Choreoapethetosis *Marked degeneration of caudate nucleus * Enlarged lateral and third ventricles * Fibrillary gliosis |
Huntington's Disease
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* Ataxia diagnosed in first decade of life; starts as gait ataxia and clumsiness
* Decreased frataxin * Joint position impaired, pain and temp sometimes lost * Death by pulmonary infection or cardiac disease * Degeneration of subcortical neurons * Pes cavus and kyphoscoliosis * Enlarged heart |
Fredreich's ataxia
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