Case 3 Immuno

Front 1

The microb. molecules that are the targets of innate immunity are sometimes called

Back 1

PAMPS - pathogen associated molecular patterns

Front 2

Adaptive immunity recognizes _____ but innate immunity is less easily tricked by microbes because it recognizes ____ _ __ _ _ __

Back 2

Antigens, functional forms of the microbes that they need to exist

Front 3

Are innate immune system receptors produced by somatic recombiination of genes or encoded in the germline?

Back 3

Encoded in the germline

***SO the specificity of the adaptive immunity is much more diverse than innate

Front 4

What does the innate system recognize on molecules released by stressed or necrotic cells

Back 4

DAMPS - damage assoc. molecular patterns

Front 5

The two principal reactions of the innate immune system are __ and ___

Back 5

Inflammation and anti viral defense

Front 6

What innate receptor recognizes:
Bacterial Peptidoglycan,
Lipoprotein,
Lipotechoic acid

Back 6

TLR-1, -2, -6

Front 7

What innate receptor recognizes:
Gram NEGATIVE bacterial LPS,
Fungal Mannans,
Viral Envelope proteins

Back 7

TLR-4

Front 8

What innate receptor recognizes:
Bacterial Flagellan

Back 8

TLR-5

Front 9

What is TLR-2 specific for

Back 9

Bacterial Lipoglycans

Front 10

TLR-3, 7, and 8 is specific for

Back 10

Viral Nucleic Acids

Front 11

TLR-4 is specific for

Back 11

Bacterial LPS

Front 12

TLR-5 is specific for

Back 12

Bacterial Flagella

Front 13

TLR-9 is specific for

Back 13

unmethylated CG-rich oligonucleotides - more abundant in bacteria than mammallian cells

Front 14

TLR stimulates two important trancription factors - ____ - which promotes cytokine and endothetlial adhesion molecule expression
_____ - which stimulates production of type I interferons, n' cytoklines that block viral replication

Back 14

NF-kB, IRF-3

Front 15

Three ways the skin/epithelia protects from infection

Back 15

Physical Barrier
Killing of microbes by locally produced peptide antibiotics
Killing of microbes and infected cells by Intraepithelial Lymphocytes

Front 16

Two cytokines that act on endothelium at site of infection causing expression of E selectin and P selectin

Back 16

TNF, IL-1

Front 17

Circulating macrophages bind strongly/weakly to selectins and strongly/weakly to integrins

Back 17

Weakly to selectins, Strongly to integrins

Front 18

What enzyme in the phagolysosome converts oxygen into superoxide anion and free radicals?

Back 18

Phagocyte oxidase

Front 19

Inherited definciency of the phagocyte oxidase enzyme cuases the immunodeficiency dx ___

Back 19

Chronic Granulomatous Disease

Front 20

____ ____ cells recognize infected and stressed cells and respond by killin em, and secreting IFN-y

Back 20

NK cells

Front 21

Macrophages with ingested microbes secrete ____ which causes the NK cells to secrete ____ which leads to microbe destruction

Back 21

IL-12, IFN-y

Front 22

The NKG2D NK cell receptor recognizes molecules that resemble ____ __ _ _ _

Back 22

Class I MHC proteins

Front 23

NK cells are inhibited by SELF class I MHC molecules which are expressed on _______

Back 23

ALL healthy nucleated cells

Front 24

Three NK activating cytokines (IL's)

Back 24

IL-15 (important for NK cell develop. maturation)
IL-12, type I interferons (help NK cells murder others)

Front 25

Three functions of the complement system

Back 25

Opsonization, Inflammation, Lysis of microbe

Front 26

Macrophages with ingested microbes secrete ____ which causes the NK cells to secrete ____ which leads to microbe destruction

Back 26

IL-12, IFN-y

Front 27

The NKG2D NK cell receptor recognizes molecules that resemble ____ __ _ _ _

Back 27

Class I MHC proteins

Front 28

NK cells are inhibited by SELF class I MHC molecules which are expressed on _______

Back 28

ALL healthy nucleated cells

Front 29

Three NK activating cytokines (IL's)

Back 29

IL-15 (important for NK cell develop. maturation)
IL-12, type I interferons (help NK cells murder others)

Front 30

Three functions of the complement system

Back 30

Opsonization (C3b),
Inflammation (C3a, C5a)
Lysis of microbe

Front 31

Name the three cytokines involved in recruiting blood neutrophils and monocytes to site of infection

Back 31

TNF
IL-1
Chemokines

Front 32

This cytokine promotes thrombus formation and reduces BP by reducing heart contractility and causing vascular leakiness

Back 32

TNF

-NOTE-
Very high levels of TNF produced in response to severe bacterial infection can cause the early clinical presentation of SEPTIC SHOCK

Front 33

What cytokine is considered a cytokine of both innate and adaptive immunity

Back 33

IFN-y

Front 34

What intracellular bacteria resists destruction inside phagocytes

Back 34

Listeria monocytogenes

Front 35

Org. resistant to phagocytosis

Back 35

Pneumococci