Care Viii - Pharmacology - Drug Abuse - Lecture 22

Front 1

What is the end result of drug seeking behavior?

Back 1

self-administration

Front 2

Tolerance can be explained in two ways. Explain them.

Back 2

1. The effect of a specific dosage decreases with repeated administration.
2. A higher dosage is needed to produce the same effect with repeated administration.

Front 3

What are the three mechanisms of repeated tolerance?

Back 3

1. dispositional tolerance
2. pharmacodynamic tolerance
3. behavioral tolerance

Front 4

Which type of tolerance is this... due to changes in the pharmacokinetic properties of the drug (absorption, distribution, metabolism and/or elimination)

Back 4

dispositional tolerance

Front 5

Which type of tolerance is this... due to adaptive changes in the affected systems (down-regulation of receptors, compensatory physiological changes)

Back 5

pharmacodynamic tolerance

Front 6

Which type of tolerance is this... an individual alters their behavior in order to adapt or compensate for the presence of the drug

Back 6

behavioral tolerance

Front 7

Which term describes the following...if tolerant to one drug in a catagory, then tolerant to all drugs in that catagory?

Back 7

cross-tolerance

Front 8

Which term describes the following...if one drug in a catagory relieves dependence, then all drugs in that catagory relieve dependence?

Back 8

cross-dependence

Front 9

There is a 98% correlation between what an animal will self administer and what a human will self administer. What are the 2 exceptions to this?

Back 9

1. hallucinogens
2. THC (active ingredient in marijuana)

Front 10

_________ is defined by the presence of "withdrawl" or abstinence syndrome, which is characterized by signs and symptoms usually opposite to those produced by the acute administration of the drug.

Back 10

physical dependence

Front 11

_______________ is the enduring problem with drug abuse and can occur independently of physical dependence.

Back 11

psychological/behavioral dependence

Front 12

true or false: psychological dependence is the big problem...it's what you treat.

Back 12

true

Front 13

Physical dependence or no physical dependence?

cannabinoids

Back 13

no physical dependence

Front 14

Physical dependence or no physical dependence?

CNS stimulants

Back 14

no physical dependence

Front 15

Physical dependence or no physical dependence?

dissociative anesthetics (ketamine and PCP)

Back 15

physical dependence
withdrawls can be life threatening!!!!

Front 16

Physical dependence or no physical dependence?

hallucinogens

Back 16

no physical dependence

Front 17

Physical dependence or no physical dependence?

opioids

Back 17

physical dependence
withdrawls are NOT life threatening

Front 18

Physical dependence or no physical dependence?

sedative-hypnotics (barbiturates and benzodiazepines)

Back 18

physical dependence
withdrawls are life threatening!!!!

Front 19

Physical dependence or no physical dependence?

volatile intoxicants
(anesthetics and solvants)

Back 19

no physical dependence

Front 20

true or false:
There is a cross-tolerance between volatile intoxicants and CNS depressants.

Back 20

true

Front 21

The drug used for substitution therapy is....

Back 21

methadone.

Front 22

The drug used for antagonist therapy is...

Back 22

naltrexone

Front 23

The drug used for contingency therapy is...

Back 23

disulfram