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22 Cards in this Set

  • Front
  • Back
cardiac output is measured in
mls per minute
filling of the heart by blood returning from the veins determines
preload
total tension =
active tension +resting tension
contractility is defined as the change in
peak isometric force at a given intial fiber length (end diastolic volume)
mean arterial pressure =
cardiac output X resistance
pressure ( mean arterial pressure ) is maintained by modulating
cardiac output and arteriolar resistance
MAP (mean arterial pressure)=
diastolic pressure +pulse pressure/3
systolic pressure
peak pressure as blood is ejected
diastolic pressure
pressure when aortic valve is closed
venous return determines.... volume
end diastolic
increased stroke volume can be achieved by
increasing muscle length ( venous return)
increasing contractility (force generated for any given length) by increasing intracellular Ca during contraction
length tension relationship of heart muscle allows for equilization of output from left and right sides of the heart. eg...
increased output from Right side of heart leads to increased filling of Left ventricle (increased EDV) and therefore increased stretch of myocardial fibers and increased force development in Left ventricle and increase Left ventricular output
increased arterial blood pressure leads to .... afterload and a ... in volume of blood ejected from the heart with each beat (ejection fraction). the resultant .... in end systolic volume and end diastolic volume.... cardiac muscle stretch, thereby.... force of contraction and... ....
higher
reduction
increase
increases
increasing
stroke volume
venous return determines.... volume
end diastolic
increased stroke volume can be achieved by
increasing muscle length ( venous return)
increasing contractility (force generated for any given length) by increasing intracellular Ca during contraction
length tension relationship of heart muscle allows for equilization of output from left and right sides of the heart. eg...
increased output from Right side of heart leads to increased filling of Left ventricle (increased EDV) and therefore increased stretch of myocardial fibers and increased force development in Left ventricle and increase Left ventricular output
increased arterial blood pressure leads to .... afterload and a ... in volume of blood ejected from the heart with each beat (ejection fraction). the resultant .... in end systolic volume and end diastolic volume.... cardiac muscle stretch, thereby.... force of contraction and... ....
higher
reduction
increase
increases
increasing
stroke volume
positive inotrope
any agent that increases peak isometric tension at a fixed length
inotropes act by modulating
Ca levels in cardiac muscle cells
binding of noradrenaline to beta adrenergic receptors on cardiac myocytes leads to
-activation of adenyl cyclase
-increased intracellular cAMP
- phosphorylation of VOCC
-increased inward movement of Ca
-increased Ca Release from sarcoplasmic reticulum and over time more stored Ca id SR
-increased actino-myosin cross briding
-increased force of contraction