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33 Cards in this Set

  • Front
  • Back
Drug for erectile dysfunction?
SIldenafil and vardenafil

"Fill the penis"
Mechanisms of SIldenafil and vardenafil
inhibit cGMP phosphodiesterase, causing increase in cGMP. smooth muscle relaxation in the corpus cavernosum, increase blood flow and penile erection
Toxicity of SIldenafil and vardenafil?
heachache, flushing, dyspepsia, imaired blue-green color vision. Risk of life-threatening hypotension in pts taking nitrates.

"Hot and sweaty", but then Headache, Heartburn, Hypotension"
Drug used for intermittent claudication
Cilostazol "For STAZis in your lower legs and Claudication use Cilostazol"
Mechanism of Cilostazol?
inhibits phosphodiesterase III. Diltes lower leg blood vessels
Calcium channel blockers
Verapamil, Diltiazem
Side effects of Calcium channel blockers (verapamil, Diltiazem)
Constipation, flushing, edema, CV effects (CHF, AV block, sinus node depression)
What diuretic would you give to a pt with acute exacerbations of CHF?
Bumetanide or Furosimide

"The BUM was so FURIous that he gave himself CHF"
Hydrochlorothiazide
-inhibits NaCl reabsorption in early distal tubule
-toxicity: Hypokalemia, hyponatremia, metabolic alkalosis
hyperGlycemis, hyperLipidemia, hyperUricemia, and hyperCalcemia, Sulfa allergy

"hyperGLUC"
Antiarrhythimics: K+ channel blockers
Sotalol, ibutilide, bretyilum, dofetilide and amiodarone

K, SO BRETY was AMOIng the DOFETILs and iBUTiflies
Toxicity of amiodorone
Pulmonary fibrosis, hepatoxicity, hypothyroidism/hyperthyroidism. Corneal deposits, skin deposits (blue/gray) resulting in photodermatitis, neurologic effects, constipations and heart block

"Remember to check PFTs, LFTs and TFTs"

"AMI was a crazy bisexual (she went both ways), a drinker and a smoker (lung and liver problems). She had beutiful eyes but had bad skin bc she always went out into the sun"
Antiarrhythimics: Na+ channel blockers list Class IA
Quinidine, Procainamide, Disopyramide

"The queen prolaims Disco's pyramid"
Antiarrhythimics: Na+ channel blockers list Class IB
Lidocaine, Mexiletine, Tocainide

"I'd Buy Lidy's Mexican Tacos"
Antiarrhythimics: Na+ channel blockers list Class IC
Flecainide, Encainide, Propafenone

The ENdangered FLEa PROfessed his love for class C"
Antiarrhythimics: Na+ channel blockers Class IA. How do they work?
(Quinidine, Procainamide, Disopyramide)
-Increase refractory period
-increase QT interval
-Affects both atria and ventricle
-SVT

"the Queen increases the QT interval and rules over both the atria and the ventricle"
Antiarrhythimics: Na+ channel blockers Class IB. How do they work?
-(Lidocaine, Mexiletine, Tocainide)
-Decrease AP duration
-Preferntially affects ischemic or depolarized purkinje and vetricle tissue
-NOT atrial tissue

"Lidy does not cell her tacos in the atria so her Assets have decreased"
Antiarrhythimics: Na+ channel blockers Class IC. How do they work?
(Flecainide, Encainide, Propafenone)
-No effect on AP duration
-Useful in V-tachs that progress to VF
-Usually last resort

"The flea was only a last resort"
Short acting beta blocker used as an Antiarrhythimic?
esmolol
How do Antiarrhythimic Calcium channel blockers work?
-Primarily affect AV nodal cells
-Decreases conduction velocity, increases ERP and increases PR interval.
-Used to prevent SVT
Adensoine
-increases K+ out of cells--> hyperpolarizing the cell and decreases Calcium.
-Drug of choice in diagnosing/abolishing SVT
-very short acting
Toxicity of adenosine?
flushing, hypotension, chest pain
K+ used for the heart?
depresses ectopic pacemakers in hypokalemia (digioxin toxicity)
Mg+ used for the heart?
Effective torsades de pointed and digitoxin toxicity
In what dz are ace inhibitors C/I
Hereditary angioedema, and bilateral renal stenosis
list ace inhibitors
caplopril, enalapril, lisinopril
Mechanism of ace inhibitors
reduce angiotension II, prevent inactivation of bradykinin and Renin release increases due to feedback inhibition
toxicity of ace inhibitors?
CAPTOPRIL
-Cough
-Angioedema
-Protinuria
-Taste changes
-hypOtension
-Pregancy problems
-Rash
-Increased Renin
-Lower angiotension II

HYPERKALEMIA
Furosemide
-Sulfonamide loop diuretic
-inhibits Na/K/Cl symporter causing hypo everything
-use for CHF
-toxicity: ototoxcity, hypokalemia, dehydration, allergy, nephritis, gout "OH DANG"

"loops lose K and Ca"
"Furosemide is a Sulfonamide" unlike Ethecrynic acid
and OH
-statin side effect?
hepatotoxicity (increased LFTs) and rhabdomyloysis. Pt present with muscle cramps and myoglobinuria
niacin side effects
-red flushed face
-decreased by asprin
-hyperglycemia (acanthosis nigrans)
-Hyperuricemia (execerbates gout)
Bile acid resin side effects
-tastes bad and causes GI discomforrt
-decrease absorption of fat-soluble vitamins
-cholesterol gallstones
Cholesterol absorption blocker side effect
-(ezetimibe)
-rare increase in LFTs
Fribrates side effect
-myositis
-hepatoxicty
-cholesterol gallstones