Cardio/renal Drugs

Front 1

Drug for erectile dysfunction?

Back 1

SIldenafil and vardenafil

"Fill the penis"

Front 2

Mechanisms of SIldenafil and vardenafil

Back 2

inhibit cGMP phosphodiesterase, causing increase in cGMP. smooth muscle relaxation in the corpus cavernosum, increase blood flow and penile erection

Front 3

Toxicity of SIldenafil and vardenafil?

Back 3

heachache, flushing, dyspepsia, imaired blue-green color vision. Risk of life-threatening hypotension in pts taking nitrates.

"Hot and sweaty", but then Headache, Heartburn, Hypotension"

Front 4

Drug used for intermittent claudication

Back 4

Cilostazol "For STAZis in your lower legs and Claudication use Cilostazol"

Front 5

Mechanism of Cilostazol?

Back 5

inhibits phosphodiesterase III. Diltes lower leg blood vessels

Front 6

Calcium channel blockers

Back 6

Verapamil, Diltiazem

Front 7

Side effects of Calcium channel blockers (verapamil, Diltiazem)

Back 7

Constipation, flushing, edema, CV effects (CHF, AV block, sinus node depression)

Front 8

What diuretic would you give to a pt with acute exacerbations of CHF?

Back 8

Bumetanide or Furosimide

"The BUM was so FURIous that he gave himself CHF"

Front 9

Hydrochlorothiazide

Back 9

-inhibits NaCl reabsorption in early distal tubule
-toxicity: Hypokalemia, hyponatremia, metabolic alkalosis
hyperGlycemis, hyperLipidemia, hyperUricemia, and hyperCalcemia, Sulfa allergy

"hyperGLUC"

Front 10

Antiarrhythimics: K+ channel blockers

Back 10

Sotalol, ibutilide, bretyilum, dofetilide and amiodarone

K, SO BRETY was AMOIng the DOFETILs and iBUTiflies

Front 11

Toxicity of amiodorone

Back 11

Pulmonary fibrosis, hepatoxicity, hypothyroidism/hyperthyroidism. Corneal deposits, skin deposits (blue/gray) resulting in photodermatitis, neurologic effects, constipations and heart block

"Remember to check PFTs, LFTs and TFTs"

"AMI was a crazy bisexual (she went both ways), a drinker and a smoker (lung and liver problems). She had beutiful eyes but had bad skin bc she always went out into the sun"

Front 12

Antiarrhythimics: Na+ channel blockers list Class IA

Back 12

Quinidine, Procainamide, Disopyramide

"The queen prolaims Disco's pyramid"

Front 13

Antiarrhythimics: Na+ channel blockers list Class IB

Back 13

Lidocaine, Mexiletine, Tocainide

"I'd Buy Lidy's Mexican Tacos"

Front 14

Antiarrhythimics: Na+ channel blockers list Class IC

Back 14

Flecainide, Encainide, Propafenone

The ENdangered FLEa PROfessed his love for class C"

Front 15

Antiarrhythimics: Na+ channel blockers Class IA. How do they work?

Back 15

(Quinidine, Procainamide, Disopyramide)
-Increase refractory period
-increase QT interval
-Affects both atria and ventricle
-SVT

"the Queen increases the QT interval and rules over both the atria and the ventricle"

Front 16

Antiarrhythimics: Na+ channel blockers Class IB. How do they work?

Back 16

-(Lidocaine, Mexiletine, Tocainide)
-Decrease AP duration
-Preferntially affects ischemic or depolarized purkinje and vetricle tissue
-NOT atrial tissue

"Lidy does not cell her tacos in the atria so her Assets have decreased"

Front 17

Antiarrhythimics: Na+ channel blockers Class IC. How do they work?

Back 17

(Flecainide, Encainide, Propafenone)
-No effect on AP duration
-Useful in V-tachs that progress to VF
-Usually last resort

"The flea was only a last resort"

Front 18

Short acting beta blocker used as an Antiarrhythimic?

Back 18

esmolol

Front 19

How do Antiarrhythimic Calcium channel blockers work?

Back 19

-Primarily affect AV nodal cells
-Decreases conduction velocity, increases ERP and increases PR interval.
-Used to prevent SVT

Front 20

Adensoine

Back 20

-increases K+ out of cells--> hyperpolarizing the cell and decreases Calcium.
-Drug of choice in diagnosing/abolishing SVT
-very short acting

Front 21

Toxicity of adenosine?

Back 21

flushing, hypotension, chest pain

Front 22

K+ used for the heart?

Back 22

depresses ectopic pacemakers in hypokalemia (digioxin toxicity)

Front 23

Mg+ used for the heart?

Back 23

Effective torsades de pointed and digitoxin toxicity

Front 24

In what dz are ace inhibitors C/I

Back 24

Hereditary angioedema, and bilateral renal stenosis

Front 25

list ace inhibitors

Back 25

caplopril, enalapril, lisinopril

Front 26

Mechanism of ace inhibitors

Back 26

reduce angiotension II, prevent inactivation of bradykinin and Renin release increases due to feedback inhibition

Front 27

toxicity of ace inhibitors?

Back 27

CAPTOPRIL
-Cough
-Angioedema
-Protinuria
-Taste changes
-hypOtension
-Pregancy problems
-Rash
-Increased Renin
-Lower angiotension II

HYPERKALEMIA

Front 28

Furosemide

Back 28

-Sulfonamide loop diuretic
-inhibits Na/K/Cl symporter causing hypo everything
-use for CHF
-toxicity: ototoxcity, hypokalemia, dehydration, allergy, nephritis, gout "OH DANG"

"loops lose K and Ca"
"Furosemide is a Sulfonamide" unlike Ethecrynic acid
and OH

Front 29

-statin side effect?

Back 29

hepatotoxicity (increased LFTs) and rhabdomyloysis. Pt present with muscle cramps and myoglobinuria

Front 30

niacin side effects

Back 30

-red flushed face
-decreased by asprin
-hyperglycemia (acanthosis nigrans)
-Hyperuricemia (execerbates gout)

Front 31

Bile acid resin side effects

Back 31

-tastes bad and causes GI discomforrt
-decrease absorption of fat-soluble vitamins
-cholesterol gallstones

Front 32

Cholesterol absorption blocker side effect

Back 32

-(ezetimibe)
-rare increase in LFTs

Front 33

Fribrates side effect

Back 33

-myositis
-hepatoxicty
-cholesterol gallstones