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19 Cards in this Set
- Front
- Back
types cardiomyopathies and typical dysfunction
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1) Dilated: impaired systolic contraction
2) Hypertrophic: impaired diastolic relaxation (usually intact systolic) 3) restrictive: abnormally stiff, impaired diastolic relaxation LA enlargement is common to all three types |
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definition cardiomyopathy
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group of heart disorders in which major structural abnormality is limited to the myocardium
- often result in symptoms of heart failure LA enlargement is common to all types excludes heart impairment from other defined CV diseases many times etiology remains unknown |
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Etiology of DCM
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1) Idiopathic
2) Familial/genetic 3) Inflammatory: - progression of viral myocarditis (immune-mediated injury?) = coxsackievirus group B = parvovirus B19 = adenovirus etc Non infectious: - peripartum CM - HF symptoms in last month of pregnancy - 6m postpartum - CT disease - Sarcoidosis 4) Toxic - alcoholic CM - potentially reversible if identified! - chemotherapeutic agents 5) Metabolic - Hyperthyroidism - Chronic hypoCa+ or hypophosphatemia 6) Neuromuscular |
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increased risk of thromboembolic complication in DCM because:
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1) stasis in ventricles from poor systolic funciton
2) stasis in atria due to chamber enlargement or a Fib 3) venous stasis from poor circulatory flow definite anticoags if: A fib previous TE intercardiac thrombus visualized w Echo LV EF <30% probably anticoag |
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Treatment considerations in DCM
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1) tx HF: diuretics, vasodilator (ACE inhib, ARB); beta-blocker
2) prevent and tx arrythmias - maintain electrolyte balance - amiodrone - ICD* - cardiac resynchronization therapy 3) Prevent thromboebolic events - anticoagulants 4) Cardiac transplant - better 5 yr prognosis than other tx |
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definition HCM
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usually asymmetric LV hypertrophy (90% cases septum) NOT caused by chronic pressure overload (ie systemic HTN or aortic stenosis)
thick muscle = stiff = impaired relaxation/filling and high diastolic pressures; also arrythmias may have transient obstruction of LV outflow during systole hypertrophy = chaotic, disarray |
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HCM etiology
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familial
autosomal dominant variable penetrance 100s of mutations - all part of sarcomere complex = impaired contractile fn = compensatory hypertrophy and proliferation of fibroblasts |
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cause of outflow obstruction in HCM
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1) rapid blood flow toward aortic valve from narrowed outflow tract
2) rapid flow creates Venturi forces that draw anterior mitral valve leaflet toward septum 3) valve leaflet abuts hypertrophied septum = transient obstruction of blood flow into aorta negative inotropic drugs and conditions that enlarge LV increase distance bw valve leaflet and septum = reduced obstruction; vice versa for conditions that decrease LV size, and positive inotropic drugs |
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Clinical findings HCM
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- presentation mid 20s
- dyspnea (^ diastolic P > ^ pulm cap P) - angina (high O2 demand, narrowed smaller branches of coronary arteries in walls) - syncope (arrhythmias; a fib not well tolerated; v fib may cause sudden cardiac death) - S4, double apical impulse |
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orthostatic lightheadedness in pts with HCM and outflow tract obstruction
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- venous return to heart decreases on standing from pooling of blood in lower extremities
= decrease size LV = intensified outflow tract obstruction = reduced CO and cerebral perfusion |
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Risk factors for sudden death in HCM
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- history of syncope
- fam hx sudden death - some high risk HCM mutations - extreme hypertrophy (>30mm in thickness) incidence: 2-4% adults, 4-6% kids/adolescents |
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HCM on EKG
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- LVH, LA enlargement
- Prominent Q waves in inf and lat leads from amplified initial depol in enlarged septum - sometimes diffuse T wave inversions - A and V arrhythmias |
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HCM treatment
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1) Beta blockers
= reduced MO2 demand (decrease angina and dyspnea) = ^ passive diastolic filling time (bc dec HR) = decrease hz ventricular ectopic beats 2) Ca Channel antagonists: reduce V stiffness 3) careful use diuretics to decrease pulm congestion w/o volume depletion 4) antiarrhythmics to avoid a fib (amidrone) 5) avoid strenuous exercise 6) ICD if high risk v fib 7) myomectomy for those who dont respond to pharma - excision hypertrophied septum; percutaneous septal ablation |
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definition RCM
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characterized by abnormally rigid, but not necessarily thickened, ventricles
= impaired diastolic filling - normal/near norm systole results from: 1) fibrosis/scarring of endomyocardium 2) infiltration of myocardium by abnormal substance |
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amyloidosis
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most common recognized cause of RCM in nontropical countries
insoluble misfolded amyloid fibrils deposit in tissues 1* - tumor secretion - see most clinical cardiac issues 2* - chronic inflam conditions hereditary - point mutations senile |
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consequences of RCM
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1) elevated systemic and pulmonary venous pressures, signs of R and L vascular congestion
2) reduced ventricular cavity size w decreased SV and CO |
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differentiation of RCM from constrictive pericarditis
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diagnostic:
-transvenous endomyocardial biopsy (presence of infiltrates) - CT - MRI (both see thickened pericardium) |
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treatment RCM
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- treat underlying cause!
- symptomatic tx = salt restriction, cautious use diuretics to improve congestion = maintenance sinus rhythm = oral anticoags |
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etiologies of RCM
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Noninfiltrative
- idiopathic - scleroderma Infiltrative: - Amyloidosis - Sarcoidosis Storage diseases: - Hemochromatosis - Glycogen storage diseases Endomyocardial disease: - endomyocardial fibrosis - metastatic tumors - radiation therapy |