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29 Cards in this Set
- Front
- Back
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MOA of Enalapril
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ACE inhibitor
(inhibits conversion of Angio 1 to 2 + breakdown of bradykinin (vasodilator)) |
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SE of Captopril (4)
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ACE inhibitor
1st dose hypotension Postural Hypotension (give night) Dry Cough Renal Impairement |
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Losartan MOA
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Angiotensin II receptor antagonist
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Indication for Losartan
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If ACEi causes SE dry cough due to bradykinin elevation
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Bendrofluazide MOA
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Thiazide Diuretic
(inhibits Na readsorption) thus decreasing H20 readsorption and causing a decreased blood volume and pressure. |
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SE of Bendrofluazide (3)
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Hypokalaemia (arrythmia, fatigue)
Hyperuricaemia (gout) Hyperglycaemia |
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SE of Metoprolol (4)
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B-blocker
Bronchoconstriction (asthma) Bradycardia Fatigue, lethargy Sleep disturbanc, nightmares Rebound hypertension if stopped suddenly |
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Prazosin MOA
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a-adrenoreceptor antagonist
prevents sympathetic tonic drive and thus vasodilation |
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Doxazosin MOA
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a-adrenoreceptor antagonist
prevents sympathetic tonic drive and thus vasodilation |
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Methyldopa MOA
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a2 agonist
centrally acting displaces noradrenaline which is more active at negative feedback site thus ultimately reducing blood pressure safe in pregnancy |
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Verapamil MOA
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Ca antagonist in myocardium and smooth mm
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Ca antagonist SEs
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Heart failure
Oedema Bradycardia |
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Nifedipine MOA
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Ca antagonist
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Amlodipine MOA
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Ca antagonist
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Diltiazem MOA
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Ca antagonist
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Minoxidil MOA
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K channel agonist
Hyperpolarises smooth mm (only used when other antihypertensives failed) |
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Simvastatin MOA
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b-hydroxy-b-methylglutaryl coenzyme A reductase inhibitors!
(HMG CoA inhibitors) |
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SE Simvastatin (2)
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Reversible myositis (raised CK)
Disturbed LFTs |
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3 Fibrinolytic drugs?
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Streptokinase - activates plasminogen to form plasmin causing fibinolysis.
Anistreplase (metabolised to streptokinase) (r)tPA - recombinant tissue plasminogen activator - used when streptokinase used recently to reduce anaphylactic reactions |
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SE Quinidine, Procainamide, Disopyramide
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N&V
Anticholinergic Hypotension (Disopyramide) SLE (Procainamide) |
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Lignocaine MOA
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Class 1B : Ischaemic (refractory) Na channels
Indicated Ventricular arrythmia post MI |
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Mexiletine MOA
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Class 1B : Ischaemic (refractory) Na channels
Indicated Ventricular arrythmia post MI |
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Tocainide
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Class 1B : Ischaemic (refractory) Na channels
Indicated Ventricular arrythmia post MI |
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Quinidine MOA
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Class 1A : Sodium Channel Blockers
1 Increase depolarisation threshold 2 Slow upstroke 3 Prolong refraction |
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Procainamide MOA
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Class 1A : Sodium Channel Blockers
1 Increase depolarisation threshold 2 Slow upstroke 3 Prolong refraction |
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Disopyramide MOA
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Class 1A : Sodium Channel Blockers
1 Increase depolarisation threshold 2 Slow upstroke 3 Prolong refraction |
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Amiodarone MOA
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K channel blocker
slows repolarisation prolonged refractory period for arrythmias |
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SE of Amiodarone (5)
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Photosensitivity
Liver Damage Thyroid disorder Neuropathy Pulmonary Alveolitis |
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Verapamil - suitable treatment for angina?
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TRUE - producing vasodilation and reducing arterial resistance
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