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28 Cards in this Set
- Front
- Back
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Class 1a
MOA Drugs |
Quinidine
Procainamide Disopyramide (Block Na channels) |
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Quinidine
Use EKG SE |
Use: Ventricular arrhythmias
EKG: QRS/QT prolong. SE: Aggravation of arrythmias (quinidine syncope); thrombocytopenia, fever, rash, cinchonism, GI sx, dig-quinidine interaction (incr dig!) |
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Procainamide
Use EKG SE |
Use: Ventricular arrhythmias
EKG: QRS/QT prolong SE: Lupus-like sx, GI; insomnia, rash, hypotension, aggravates arrhythmias, blood dyscrasias |
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Disopyramide
Use EKG SE |
Use: Ventr Arrhy
EKG: QRS/QT prolong/PR prolong too SE: Anticholinergic, hypotension, heart failure, heart block, tachyarrhythmias |
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Class 1b
MOA Drugs |
Lidocaine
Phenytoin Mexiletine Tocainide MOA: Na channel blocker |
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Lidocaine
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Use: VTach, Afibb
EKG: QT shortening SE: CNS (drowsi, agitation, seizures), CHF (rare), heart block |
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Phenytoin
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Use: Ventr arrhy
EKG: QT shortening SE: CNS (ataxia, nystagmus, drowsi), hypotension, heart block with rapid IV injection! |
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Mexiletine
Tocainide |
Use: Ventr Arrhy
EKG: (like Lido) SE: GI, neurologic |
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Class 1c
MOA Drugs |
Flecainide
Propafenone |
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Flecainide
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Use: VT, SVT, WPW
EKG: Neg inotropic; QRS/PR prolong. SE: GI, CNS, incessant VT |
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Propafenone
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Use: VT, AF
EKG: Neg. inotropic SE: GI, CNS, cardiac Class 1c: contraindicated post-MI! |
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Class II/Betablockers
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Metoprolol
Atenolol Propanolol Nadolol Timolol Pindolol Acebutolol Labetolol Esmolol |
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Cardioselective beta blockers?
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Metoprolol
Atenolol Acebutolol Esmolol |
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Class III
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Amiodarone
Sotalol Ibutilide Dofetilide K+ channel blockers Can be used for WPW |
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Amiodarone
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Use: VTach, AF, AFlutter
Half-life: >50d. SE: lung toxicity (pt presents with cough, fever, painful breathing), nerve toxicity (changes in gait, tremor, imbalance, numbness, weakness), thyroid dysfunction, exagg response to sunlight, blue-gray discoloration, corneal deposits (>6 months) |
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Ibutilide
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Use: Atrial Flutter, AFibb
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Sotalol
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Use: VTach, VFibb
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Class IV
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Verapamil
Diltiazem Ca++ channel blockers |
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Verapamil
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Use: SVTs, anything atrial
SE: CHF, asystole, constipation |
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Class V: Adenosine, Digoxin
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See card
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Adenosine
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Use: SVTs, Afibb
EKG: PR prolong SE: transient dyspnea, noncardiac chest pain, hypotension (rare) |
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Digoxin
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Use: AFibb
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Non-selective beta blockers can do what in diabetics?
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Mask hypoglycemic sx!
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ADRs of Beta-blockers?
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1 Fatigue
2. Mental depression 3. Insomnia 4. ADR on lipids 5. Hallucinations 6. Raynaud 7. Bronchoconstriction 8. Sexual dysfxn 9. Mask hypoglycemia |
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Nitrates:
Low doses? |
In low doses, incr venous dilation and thus reduce preload
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Nitrates:
Medium doses? |
in medium doses, incr arteriolar dilation and subsequently decr afterload and preload
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Nitrates:
High doses? |
in high doses, incr coronary artery dilation and subseq. incr oxygen supply
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Nitrates - SE
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Orthostatic hypotension
Reflex tach Throbbing HA Blushing CI if sbp<90! |
